Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil

dc.creatorSilva, Monaíse M. O.
dc.creatorKikuti, Mariana
dc.creatorAnjos, Rosângela O.
dc.creatorPortilho, Moyra M.
dc.creatorSantos, Viviane C.
dc.creatorGonçalves, Thaiza S. F.
dc.creatorTauro, Laura B.
dc.creatorMoreira, Patrícia S. S.
dc.creatorNascimento, Leile C. Jacob
dc.creatorSantana, Perla M.
dc.creatorCampos, Gúbio S.
dc.creatorSiqueira, André M.
dc.creatorKitrona, Uriel
dc.creatorReis, Mitermayer Galvão dos
dc.creatorRibeiro, Guilherme de Sousa
dc.date2021-04-26T11:37:04Z
dc.date2021-04-26T11:37:04Z
dc.date2021
dc.date.accessioned2023-09-26T21:08:13Z
dc.date.available2023-09-26T21:08:13Z
dc.identifierSILVA, Monaíse M. O. et al. Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil. International Journal of Infectious Diseases, v. 105, p. 608–616, 1 Apr. 2021.
dc.identifier1201-9712
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/46884
dc.identifier10.1016/j.ijid.2021.03.003
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869742
dc.descriptionBrazilian National Council for Scientific and Technological Development (Grants 400830/2013-2 and 440891/2016-7 to GSR, and scholarships to LBT, UK, MGR and GSR)
dc.descriptionBahia Foundation for Research Support (PET0026/2013, APP0044/2016 and PET0022/2016 to GSR, and scholarship to MMOS)
dc.descriptionCoordination for the Improvement of Higher Education Personnel, Brazilian Ministry of Education (88881.130749/2016-01 to GSR and scholarship to MK)
dc.descriptionDepartment of Science and Technology, Secretariat of Science, Technology and Strategic Inputs, Brazilian Ministry of Health
dc.descriptionFederal University of Bahia
dc.descriptionFundação Oswaldo Cruz
dc.descriptionREPLICK (Clinical and Applied Research in Chikungunya)
dc.descriptionObjectives: To investigate risk factors for persistent arthralgia in patients with chikungunya, and describe its impact on daily activities. Methods: From September 2014 to July 2016, a surveillance study enrolled patients with acute febrile illness in Salvador, Brazil, and detected those with chikungunya virus infection using IgM enzyme-linked immunosorbent assay or reverse transcriptase polymerase chain reaction. Telephone follow-ups were performed to ascertain the progression of disease. Results: Of 153 followed cases, 65 (42.5%) reported chronic arthralgia that lasted >3 months, and 47 (30.7%) were still symptomatic at the time of the interview (approximately 1.5 years after symptom onset). Limitations in daily activities and mental distress were reported by 93.8% and 61.5% of those with chronic arthralgia, respectively. Female sex [risk ratio (RR) 1.79, 95% confidence interval (CI) 1.95–2.69] and age (RR 1.02 for each 1-year increase, 95% CI 1.01–1.03) were independent risk factors for chronic arthralgia. Chronic arthralgia was not associated with co-infection with dengue virus (RR 0.97, 95% CI 0.48–1.94) or chikungunya viral load at diagnosis (median chikungunya virus RNA of 5.60 and 5.52 log10 copies/mL for those with and without chronic arthralgia, respectively; P = 0.75). Conclusions: These findings reinforce the high frequency of chronic chikungunya arthralgia, and highlight the substantial disability associated with the persistence of pain. Development of novel strategies to mitigate the transmission of chikungunya virus and to provide long-term medical assistance for patients with chikungunya are needed urgently.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectVírus Chikungunya
dc.subjectArtralgia crônica
dc.subjectCoorte
dc.subjectFator de risco
dc.subjectIncapacidade
dc.subjectChikungunya virus
dc.subjectChronic arthralgia
dc.subjectCohort
dc.subjectRisk factor
dc.subjectDisability
dc.titleRisk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
dc.typeArticle


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