Cytogenetic evaluation of 20 primary breast carcinomas

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCavalli, L. R.
dc.creatorCavaliéri, L. M B
dc.creatorRibeiro, L. A.
dc.creatorCavalli, I. J.
dc.creatorSilveira, R.
dc.creatorRogatto, Silvia Regina
dc.date2014-05-27T11:18:17Z
dc.date2016-10-25T18:14:40Z
dc.date2014-05-27T11:18:17Z
dc.date2016-10-25T18:14:40Z
dc.date1997-11-03
dc.date.accessioned2017-04-06T00:50:27Z
dc.date.available2017-04-06T00:50:27Z
dc.identifierHereditas, v. 126, n. 3, p. 261-268, 1997.
dc.identifier0018-0661
dc.identifierhttp://hdl.handle.net/11449/65224
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65224
dc.identifier10.1111/j.1601-5223.1997.00261.x
dc.identifier2-s2.0-0030656520.pdf
dc.identifier2-s2.0-0030656520
dc.identifierhttp://dx.doi.org/10.1111/j.1601-5223.1997.00261.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886969
dc.descriptionChromosome analysis was performed on samples from 20 Brazilian patients with breast cancer. All the samples were from untreated patients who presented the clinical symptoms for months or years before surgical intervention. Six cases showed axillary lymph node metastases. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes X, 19, 20, and 22 followed by gain of chromosomes 9 and 8. Among the structural anomalies observed, there was preferential involvement of chromosomes 11, 6, 1, 7, 3, and 12, supporting previous reports that these chromosomes may harbour genes of importance in the development of breast tumors. Two cases with a family history of breast cancer had in common total or partial trisomy 1.
dc.languageeng
dc.relationHereditas
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectaxillary lymph node
dc.subjectbrazil
dc.subjectbreast cancer
dc.subjectchromosome 1
dc.subjectchromosome 11
dc.subjectchromosome 12
dc.subjectchromosome 19
dc.subjectchromosome 20
dc.subjectchromosome 22
dc.subjectchromosome 3
dc.subjectchromosome 6
dc.subjectchromosome 7
dc.subjectchromosome 8
dc.subjectchromosome 9
dc.subjectclinical article
dc.subjectcytogenetics
dc.subjectfemale
dc.subjecthuman
dc.subjectlymph node metastasis
dc.subjectmale
dc.subjectnumerical chromosome aberration
dc.subjectpartial trisomy
dc.subjectstructural chromosome aberration
dc.subjectX chromosome
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBrazil
dc.subjectBreast Neoplasms
dc.subjectBreast Neoplasms, Male
dc.subjectCarcinoma, Ductal, Breast
dc.subjectChromosome Aberrations
dc.subjectChromosome Disorders
dc.subjectChromosome Mapping
dc.subjectChromosomes, Human
dc.subjectFemale
dc.subjectHumans
dc.subjectKaryotyping
dc.subjectLymphatic Metastasis
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasms
dc.subjectTrisomy
dc.subjectX Chromosome
dc.titleCytogenetic evaluation of 20 primary breast carcinomas
dc.typeOtro


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