Tempo de latencia do rocuronio e da succinilcolina e condicoes de intubacao traqueal

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorVianna, Pedro Thadeu Galvão
dc.creatorCatiglia, Y. M M
dc.creatorGanem, Eliana Marisa
dc.creatorTakata, I. H.
dc.creatorBraz, José Reinaldo Cerqueira
dc.creatorCuri, P. R.
dc.date2014-05-27T11:18:16Z
dc.date2016-10-25T18:14:39Z
dc.date2014-05-27T11:18:16Z
dc.date2016-10-25T18:14:39Z
dc.date1997-10-15
dc.date.accessioned2017-04-06T00:50:21Z
dc.date.available2017-04-06T00:50:21Z
dc.identifierRevista Brasileira de Anestesiologia, v. 47, n. 5, p. 401-407, 1997.
dc.identifier0034-7094
dc.identifierhttp://hdl.handle.net/11449/65211
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65211
dc.identifier2-s2.0-0030863903.pdf
dc.identifier2-s2.0-0030863903
dc.identifierhttp://www.sba.com.br/arquivos/revista/rba/set97401.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886957
dc.descriptionBackground and Objectives - Pulmonary aspiration of gastric content during induction of anesthesia for emergency surgical procedures is a serious complication; fast endotracheal intubation under these circumstances is of vital importance to secure the airways. Despite its numerous side effects, succinylcholine is used for this purpose. Rocuronium is the most recently introduced aminoesteroid neuromuscular blocking drug with short onset. The objective of this study was to compare the onset time and intubating conditions of rocuronium and succinylcholine. Methods - After informed consent, forty-five patients were randomly allocated into three groups of 15: Group I (GI) = succinylcholine 1 mg.kg-1; Group II (GII) = rocuronium 0.6 mg.kg-1; Group III (GIII) = rocuronium 0.9 mg.kg-1. Every patient was premedicated with midazolam 15 mg per os and induction of anesthesia was made with fentanyl 10 μg.kg-1 and etomidate 0.3 mg.kg-1. The neuromuscular block was monitored with the TOP-Guard neuromuscular transmission monitor. The TOP-Guard neuromuscular monitor uses an accelerometer to measure the response to nerve stimulation. The stimulating electrodes were placed close to the course of the ulnar nerve at the wrist. The onset time was considered as the time between the end of neuromuscular drug injection and the twitch height (T1) decrease to 10%. Heart rate and arterial blood pressure were registered at 6 moments before and after induction of anesthesia. Results - The onset time results were: Group I, 71 s; Group II, 120 s and Group III, 70 s or GI = GIII < GII (F = 8.862; p < 0.01). There were 43 patients exhibiting excellent intubating conditions and 2 with good intubating conditions. Heart rate and arterial blood pressure showed alterations due to induction of anesthesia and intubation. Conclusions - Rocuronium 0.9 mg.kg-1 can be used in rapid sequence induction because it has a short onset time which is similar to that of succnylcholine. It is likely that rocuronium would be a good indication in patients with high intracranial pressure, burns and neuromuscular diseases.
dc.languagepor
dc.relationRevista Brasileira de Anestesiologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeuromuscular blockers: rocuronium, succinylcholine
dc.subjectfentanyl
dc.subjectmidazolam
dc.subjectneuromuscular blocking agent
dc.subjectrocuronium
dc.subjectsuxamethonium
dc.subjectanesthesia induction
dc.subjectarterial pressure
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectheart rate
dc.subjecthuman
dc.subjectnerve stimulation
dc.subjectneuromuscular blocking
dc.subjectrandomized controlled trial
dc.subjectside effect
dc.subjectulnar nerve
dc.titleTempo de latencia do rocuronio e da succinilcolina e condicoes de intubacao traqueal
dc.typeOtro


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