Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)

dc.creatorVanasco, N. B
dc.creatorSchmeling, M. F
dc.creatorLottersberger, J
dc.creatorCosta, Federico
dc.creatorKo, Albert Icksang
dc.creatorTarablae, H. D
dc.date2015-11-12T12:05:28Z
dc.date2015-11-12T12:05:28Z
dc.date2008
dc.date.accessioned2023-09-26T21:07:32Z
dc.date.available2023-09-26T21:07:32Z
dc.identifierVANASCO, N. B et al. Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005). Acta Tropica, v. 107, n. 3, p. 255-258, 2008.
dc.identifier1873-6254
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12201
dc.identifier10.1016/j.actatropica.2008.06.007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869554
dc.descriptionThere is scarce data on the burden of leptospirosis and its epidemiological characteristics in Argentina. This study aimed to evaluate distribution of leptospirosis cases and identify risk factors for the disease during national laboratory-based surveillance. From January 1999 to December 2005, 812 suspected cases were referred to the national reference laboratory, of which 182 and 463 had respectively, laboratory confirmed and unconfirmed diagnosis of leptospirosis. The diagnosis of leptospirosis was discarded in 167 cases. The most prevalent presumptive infecting serogroup was Icterohaemorrhagie followed by Pomona, Ballum and Canicola. The majority of cases occurred during the worm and rainy months. Confirmed cases were predominantly adults and males, who presented with fever, headache and myalgias. Severe clinical manifestations included jaundice and acute renal insufficiency. Conjunctival suffusion, a hallmark clinical sign of leptospirosis, was found in 55% of confirmed cases, and 43% of the cases with discarded diagnosis (p=0.036). After multivariate analyses, age >30 years (OR=2.16; 1.05-4.41), occupation in a rural setting (OR=3.41; 1.45-8.06), contact with contaminated surface water (OR=2.17; 1.01-4.68), and contact with floods (OR=4.49; 1.17-17.25) were significantly associated with leptospirosis. In conclusion, although activities associated with rural occupations remain important risk factors in Argentina, exposures occurring during flooding events have emerged to be the major risk factor for leptospirosis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectLeptospirosis
dc.subjectEpidemiology
dc.subjectRisk factors
dc.subjectMicroscopic agglutination test
dc.subjectRural transmission
dc.subjectArgentina
dc.subjectLeptospira/isolamento & purificação
dc.subjectLeptospirose/epidemiologia
dc.subjectLeptospirose/fisiopatologia
dc.subjectAdulto
dc.subjectFatores Etários
dc.subjectArgentina/epidemiologia
dc.subjectFeminino
dc.subjectHumanos
dc.subjectIncidência
dc.subjectLeptospira/classificação
dc.subjectLeptospirose/complicações
dc.subjectMasculino
dc.subjectMeis-Idade
dc.subjectFatores de Risco
dc.subjectEstações do Ano
dc.subjectFatores Sexuais
dc.titleClinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)
dc.typeArticle


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