Low level laser therapy partially restores trachea muscle relaxation response in rats with tumor necrosis factor alpha-mediated smooth airway muscle dysfunction

dc.creatorAimbire, F.
dc.creatorBjordal, J. M.
dc.creatorIversen, V. V.
dc.creatorAlbertini, R.
dc.creatorFrigo, L.
dc.creatorPacheco, M. T. T.
dc.creatorFaria Neto, Hugo Caire C.
dc.creatorChavantes, M. C.
dc.creatorLabat, R. M.
dc.creatorMartins, R. A. B. Lopes
dc.date2019-12-19T16:40:47Z
dc.date2019-12-19T16:40:47Z
dc.date2006
dc.date.accessioned2023-09-26T21:07:17Z
dc.date.available2023-09-26T21:07:17Z
dc.identifierAIMBIRE, F. et al. Low Level Laser Therapy Partially Restores Trachea Muscle Relaxation Response in Rats With Tumor Necrosis Factor a-Mediated Smooth Airway Muscle Dysfunction. Lasers in Surgery and Medicine, v. 38, p. 773-778, 2006.
dc.identifier0196-8092
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/38719
dc.identifier10.1002/lsm.20357
dc.identifier1096-9101
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869482
dc.descriptionBackground and Objective: It is unknown if the decreased ability to relax airway smooth muscles in asthma and other inflammatory airways disorders can be influenced by low level laser therapy (LLLT) irradiation. To investigate if LLLT could reduce impairment in inflamed trachea smooth muscles (TSM) in rats. Study Design/Materials and Methods: Controlled rat study where trachea was dissected and mounted in an organ bath apparatus with or without a TNF-a solution. Results: Low level laser therapy administered perpendicularly to a point in the middle of the dissected trachea with a wavelength of 655 nm and a dose of 2.6 J/cm2, partially restored TSM relaxation response to isoproterenol. Tension reduction was 47.0 % ( 2.85) in the laser-irradiated group compared to 22.0% ( 2.21) in the control group (P < 0.01). Accumulation of cAMP was almost normalized after LLLT at 22.3 pmol/mg ( 2.1) compared to 17.6 pmol/mg ( 2.1) in the non-irradiated control group (P < 0.01). Conclusion: Low level laser therapy partially restores the normal relaxation response in inflamed TSM and normalizes accumulation of cAMP in the presence of isoproterenol.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectTerapia a laser de baixo nível
dc.subjectInflamação
dc.subjectTraquéia
dc.subjectVias aéreas
dc.subjectLow level laser therapy
dc.subjectInflammation
dc.subjectTNF-alpha
dc.subjectAirway
dc.subjectTrachea
dc.subjectFator de Necrose Tumoral alfa
dc.titleLow level laser therapy partially restores trachea muscle relaxation response in rats with tumor necrosis factor alpha-mediated smooth airway muscle dysfunction
dc.typeArticle


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