Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.

dc.creatorFumagalli, Marcilio Jorge
dc.creatorCastro-Jorge, Luiza Antunes
dc.creatorFraga-Silva, Thais Fernanda de Campos
dc.creatorde Azevedo, Patrick Orestes
dc.creatorCapato, Carlos Fabiano
dc.creatorRattis, Bruna Amanda Cruz
dc.creatorHojo-Souza, Natália Satchiko
dc.creatorFloriano, Vitor Gonçalves
dc.creatorde Castro, Julia Teixeira
dc.creatorRamos, Simone Gusmão
dc.creatorda Fonseca, Benedito Antônio Lopes
dc.creatorBonato, Vânia Luiza Deperon
dc.creatorGazzinelli, Ricardo Tostes
dc.creatorFigueiredo, Luiz Tadeu Moraes.
dc.date2022-06-28T17:52:41Z
dc.date2022-06-28T17:52:41Z
dc.date2021
dc.date.accessioned2023-09-26T21:07:14Z
dc.date.available2023-09-26T21:07:14Z
dc.identifierFUMAGALLI, Marcilio Jorge et al. Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization. Viruses ; v. 13, n. 12, 2021, 2440. doi: 10.3390/v13122440
dc.identifier1999-4915
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53562
dc.identifier10.3390/v13122440
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869473
dc.descriptionThe persistent circulation of SARS-CoV-2 represents an ongoing global threat due to the emergence of new viral variants that can sometimes evade the immune system of previously exposed or vaccinated individuals. We conducted a follow-up study of adult individuals that had received an inactivated SARS-CoV-2 vaccine, evaluating antibody production and neutralizing activity over a period of 6 months. In addition, we performed mice immunization with inactivated SARS-CoV-2, and evaluated the immune response and pathological outcomes against Gamma and Zeta variant infection. Vaccinated individuals produced high levels of antibodies with robust neutralizing activity, which was significantly reduced against Gamma and Zeta variants. Production of IgG anti-S antibodies and neutralizing activity robustly reduced after 6 months of vaccination. Immunized mice demonstrated cellular response against Gamma and Zeta variants, and after viral infection, reduced viral loads, IL-6 expression, and histopathological outcome in the lungs. TNF levels were unchanged in immunized or not immunized mice after infection with the Gamma variant. Furthermore, serum neutralization activity rapidly increases after infection with the Gamma and Zeta variants. Our data suggest that immunization with inactivated WT SARS-CoV-2 induces a promptly responsive cross-reactive immunity response against the Gamma and Zeta variants, reducing COVID-19 pathological outcomes.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectSARS-CoV-2
dc.subjectGamma variant
dc.subjectZeta variant
dc.subjectcross-protection
dc.subjectinactivated vaccine
dc.titleProtective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.
dc.typeArticle


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