Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies?

dc.creatorGomes, Yara M.
dc.creatorLorena, Virginia M. B.
dc.creatorLuquetti, Alejandro O.
dc.date2018-06-29T13:56:38Z
dc.date2018-06-29T13:56:38Z
dc.date2009
dc.date.accessioned2023-09-26T21:07:03Z
dc.date.available2023-09-26T21:07:03Z
dc.identifierGOMES, Y. M.; LORENA, V. M. B.; LUQUETTI, A. O. Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies? Memorias Do Instituto Oswaldo Cruz, v. 104 Suppl 1, p. 115–121, jul. 2009.
dc.identifier1678-8060
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27192
dc.identifier10.1590/S0074-02762009000900017
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869419
dc.descriptionBiomanguinhos-Fiocruz (CC 09/2007), PDTSP-Fiocruz (PCL04), CNPq (YMG 306427/2006-0), VMBL (143023/2006-3)
dc.descriptionIn the acute phase and in the chronic forms of Chagas disease, the etiological diagnosis may be performed by detection of the parasite using direct or indirect parasitological methods and by the presence of antibodies in the serum by way of serological tests. Several techniques are easily available, ranging from the simplest wet smear preparation to immuno-enzymatic assays with recombinant antigens that will meet most diagnostic needs. Other tests under evaluation include a molecular test using polymerase chain reaction, which has shown promising results and may be used as a confirmatory test both in the acute and chronic phases of the disease. Better rapid tests are needed for diagnosis, some of which are already under evaluation. Additionally, there is a need for tools that can identify patients cured shortly after specific treatment. Other needs include a marker for prognosis and early diagnosis of congenital transmission.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectDoença de Chagas
dc.subjectTrypanosoma cruzi
dc.subjectDiagnóstico etiológico
dc.subjectChagas disease
dc.subjectTrypanosoma cruzi
dc.subjectEtiological diagnosis
dc.subjectDoença Aguda
dc.subjectAnticorpos, protozoários / sangue
dc.subjectDoença de Chagas / diagnóstico
dc.subjectDoença de Chagas / quimioterapia
dc.subjectDoença crônica
dc.subjectEnsaio de Imunoadsorção Enzimática
dc.subjectHumanos
dc.subjectImunoblotting
dc.subjectReação em Cadeia da Polimerase
dc.subjectSensibilidade e Especificidade
dc.subjectTestes Sorológicos
dc.subjectTripanocidas Agentes / uso terapêutico
dc.subjectTrypanosoma cruzi / genética
dc.subjectTrypanosoma cruzi / imunologia
dc.titleDiagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies?
dc.typeArticle


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