Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.

dc.creatorCosta, Af Ali Uthant Moreira Lima da
dc.creatorAbreu, Ana Lucia
dc.creatorGomes, Claudia Maria de Castro
dc.creatorSaldanha, Ana Cristina Rodrigues
dc.creatorBarral, Aldina Maria Prado
dc.creatorCosta, Jackson Mauricio Lopes
dc.creatorCorbett, Carlos Eduardo Pereira
dc.date2014-12-18T11:59:57Z
dc.date2014-12-18T11:59:57Z
dc.date2006
dc.date.accessioned2023-09-26T21:07:01Z
dc.date.available2023-09-26T21:07:01Z
dc.identifierCOSTA, Af Ali U. M. et al. Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. Acta Tropica, v. 98, n. 2, p. 125-129, 2006.
dc.identifier0001-706X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9212
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869410
dc.descriptionExperimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous form (DCL), the mechanisms are still unknown. In the present study, we determined these alterations in an animal model susceptible to Leishmania (L) amazonensis. Amastigotes of L. (L) amazonensis isolated from patients with diffuse cutaneous leishmaniasis (DCL) were inoculated into the hind paws of eight BALB/c mice, macroscopic and histopathological aspects were analyzed. After 90 and 120 days of evolution, histopathological analysis demonstrated a mononuclear cell infiltrate rich in plasma cells and intense parasitism of intra- and extra-medullary macrophages, with areas of bone necrosis and discrete involvement of cartilaginous tissue. The results show that the inflammatory process developed during L. (L) amazonensis infection might cause bone tissue destruction and secondarily affect the joints
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectOsteomyelitis
dc.subjectPathology
dc.subjectDiffuse cutaneous leishmaniasis
dc.subjectExperimental model
dc.subjectLeishmania/crescimento & desenvolvimento
dc.subjectLeishmaniose Tegumentar Difusa/patologia
dc.subjectOsteomielite/parasitologia
dc.subjectAnimais
dc.subjectModelos Animais de Doenças
dc.subjectMembro Posterior/parasitologia
dc.subjectMembro Posterior/patologia
dc.subjectHistocitoquímica
dc.subjectHumanos
dc.subjectLeishmaniose Tegumentar Difusa/imunologia
dc.subjectLeishmaniose Tegumentar Difusa/parasitologia
dc.subjectMacrófagos/imunologia
dc.subjectMacrófagos/parasitologia
dc.subjectMacrófagos/patologia
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectOsteomielite/imunologia
dc.subjectOsteomielite/patologia
dc.titleExperimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
dc.typeArticle


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