Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.

dc.creatorLanzaro, G. C
dc.creatorLopes, Angela Hampshire de Carvalho Santos
dc.creatorRibeiro, José Marcos Chaves
dc.creatorShoemaker, Charles B
dc.creatorWarburg, A
dc.creatorSoares, Milena Botelho Pereira
dc.creatorTitus, Richard G
dc.date2015-04-07T14:02:23Z
dc.date2015-04-07T14:02:23Z
dc.date1999
dc.date.accessioned2023-09-26T21:06:51Z
dc.date.available2023-09-26T21:06:51Z
dc.identifierLANZARO, G. C. et al. Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex. Insect Molecular Biology, v. 8, n. 2, p. 267-275, 1999.
dc.identifier0962-1075
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9909
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869368
dc.descriptionMaxadilan is an approximately 7kDa peptide that occurs in the saliva of the sand fly Lutzomyia longipalpis. This peptide is a potent vasodilator and may also have immunomodulatory effects related to the pathogenesis of leishmanial infections. Variation in the primary DNA and inferred amino acid sequence of maxadilan is reported. Differences were found within and among natural field populations as well as among sibling species. Extensive amino acid sequence differentiation, up to 23%, was observed among maxadilan from different populations. This is a remarkable degree of polymorphism considering the small size of this peptide. The vasodilatory activity of maxadilan was equivalent among recombinant maxadilan variants. All maxadilan variants induce interleukin-6. Predicted secondary structure and hydrophobicity plots suggest that these characteristics are conserved among variant peptides. However, profiles based on the antigenic index do differ among peptides.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBlackwell Science
dc.rightsopen access
dc.subjectMaxadalin
dc.subjectPopulation genetics
dc.subjectSaliva
dc.subjectVasodilator
dc.subjectProteínas de Insetos/farmacologia
dc.subjectPsychodidae
dc.subjectProteínas e Peptídeos Salivares/farmacologia
dc.subjectVasodilatadores/farmacologia
dc.subjectAnimais
dc.subjectSequência de Bases
dc.subjectDNA
dc.subjectProteínas de Insetos/química
dc.subjectInterleucina-6/biossíntese
dc.subjectMacrófagos Peritoneais/efeitos de drogas
dc.subjectDados de Sequência Molecular
dc.subjectEstrutura Secundária de Proteína
dc.subjectCoelhos
dc.subjectProteínas e Peptídeos Salivares/química
dc.subjectVasodilatadores/química
dc.subjectVasodilatadores/classificação
dc.titleVariation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.
dc.typeArticle


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