Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice

dc.creatorTendler, Miriam
dc.creatorPinto, Roberto Magalhães
dc.creatorLima, Antonio de Oliveira
dc.creatorSavino, Wilson
dc.creatorKatz, Naftale
dc.date2019-06-23T15:09:06Z
dc.date2019-06-23T15:09:06Z
dc.date1992
dc.date.accessioned2023-09-26T21:06:20Z
dc.date.available2023-09-26T21:06:20Z
dc.identifierTENDLER, Miriam et al. Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 1, p. 281-286, 1992.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33623
dc.identifier10.1590/S0074-02761992000500053
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869227
dc.descriptionPrevious studies have shown that both permissive (mouse) and partially permissive (rabbit) hosts develop high levels of resistance against Schistosoma mansoni infection after vaccination with a multiple antigen extract (SE) obtained by incubation of living adult worms in saline, plus bacterial adjuvant. To investigate variables influencing SE-induced protection in murine schistosomiasis, a series of distinct vaccination protocols were performed focussing on the immunization dose, carrier systems, route, site and amplitude of challenge infection, and time between immunization and challenge. In addition, a new approach was adopted to evaluate SE protective activity, by means of population analysis of worm burden frequency distributions in a large scale study of vaccination in outbred Swiss mice. Distinct curves of frequency and a drastic difference in worm burden distribution of frequencies from SE-vaccinated × non-vaccinated mice were found. It was shown that SE could generate 75% mean protection in outbred mice even in the absence of adjuvant. In addition SE immunization was also able to induce full protection against lethal infection. SE-induced protection could be modulated by such parameters as dose of SE immunization/challenge interval, and route of cercariae injection. These data show that SE yields very high protective activity in outbred mice, and may provide a further insight for rational design of a vaccine in experimental schistosomiasis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectVacinação
dc.subjectSchistosoma mansoni
dc.subjectAntígenos
dc.subjectModelo murino
dc.subjectVaccination
dc.subjectSchistosoma mansoni
dc.subjectMurine model
dc.subjectAntigens
dc.titleVaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
dc.typeArticle


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