Factors Associated with Clinical and Topographical Features of Laryngeal Tuberculosis

dc.creatorReis, João Gustavo Corrêa
dc.creatorReis, Clarissa Souza Mota
dc.creatorCosta, Daniel César Silva da
dc.creatorLucena, Márcia Mendonça
dc.creatorSchubach, Armando de Oliveira
dc.creatorOliveira, Raquel de Vasconcellos Carvalhaes de
dc.creatorRolla, Valéria Cavalcanti
dc.creatorSilva, Fátima Conceição
dc.creatorRosalino, Cláudia Maria Valete
dc.date2016-12-11T17:48:59Z
dc.date2016-12-11T17:48:59Z
dc.date2016
dc.date.accessioned2023-09-26T21:05:53Z
dc.date.available2023-09-26T21:05:53Z
dc.identifierREIS, João Gustavo Corrêa; et al. Factors Associated with Clinical and Topographical Features of laryngeal Tuberculosis . Plos One, v.11, n.4, e0153450, 14p, Apr. 2016
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16505
dc.identifier10.1371/journal.pone.0153450
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869101
dc.descriptionAbstract INTRODUCTION: Laryngeal tuberculosis (LTB) is the most frequent granulomatous disease of the larynx and represents less than 2% of extrapulmonary TB cases. There are no pathognomonic clinical and endoscopic features of this disease and studies on LTB that can assist in its diagnostic characterization are lacking. OBJECTIVE: To identify factors associated with clinical and topographical features of LTB. METHOD: a retrospective cross-sectional study was conducted from the medical records of 36 patients with confirmed LTB diagnosis. RESULTS: Dysphonia and cough were the main symptoms presented by patients and the true vocal folds the most frequently affected site. The average of the duration of the disease evolution was significantly higher in patients with dysphonia than in patients without this symptom. We observed association between dysphonia and true vocal fold lesions and between odynophagia and lesions in the epiglottis, arytenoids and aryepiglottic folds. Odynophagia was more frequent in individuals with lesions in four or more laryngeal sites. Weight loss equal or above 10% of the body weight was more frequent in patients with odynophagia as first symptom and in patients with ulcerated lesion. Dyspnea on exertion was more frequent in individuals with more extensive laryngeal lesions. The percentage of smokers with lesions in four or more laryngeal sites was greater than that found in non-smokers. Laryngeal tissue fragment bacilloscopy and culture examinations were less positive than sputum ones. CONCLUSIONS: Smoking appears to be associated with the development of more extensive LTB lesions, and LTB with dyspnea on exertion and odynophagia with consequent impairment of nutritional status. We emphasize the need for histopathologic confirmation, once positive sputum bacteriological examinations seem not to necessarily reflect laryngeal involvement.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectTuberculose laríngea
dc.subjectCaracterísticas clínicas e topográficas
dc.subjectFatores Associados
dc.subjectLaryngeal Tuberculosis
dc.subjectClinical and Topographical Features
dc.subjectFactors Associated
dc.titleFactors Associated with Clinical and Topographical Features of Laryngeal Tuberculosis
dc.typeArticle


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