| dc.creator | Silva, Walter A. Eyer | |
| dc.creator | Morgado, Mariza G. | |
| dc.date | 2020-11-23T13:47:27Z | |
| dc.date | 2020-11-23T13:47:27Z | |
| dc.date | 2007 | |
| dc.date.accessioned | 2023-09-26T21:05:38Z | |
| dc.date.available | 2023-09-26T21:05:38Z | |
| dc.identifier | SILVA, Walter A. Eyer; MORGADO, Mariza G. Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 7, p. 809-815, Nov. 2007. | |
| dc.identifier | 0074-0276 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/44584 | |
| dc.identifier | 10.1590/S0074-02762007005000112 | |
| dc.identifier | 1678-8060 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8869036 | |
| dc.description | As part of an ongoing study on the features of AIDS spread towards small cities and rural areas, we present
a molecular survey of human immunodeficiency virus type 1 (HIV-1) polymerase sequences recovered between
2004 and 2006 from 71 patients receiving care in the city of Saquarema, inner state of Rio de Janeiro. Phylogenetic reconstructions found the two prevalent lineages in the state (subtypes B [59 strains, 83.1%], F1 [6 strains;
8.4%], and BF1 recombinants [four strains; 5.6%]), as well as two (2.8%) CRF02_AG strains, which seems to
be an emerging lineage in the capital. These CRF02_AG sequences were recovered from a married heterosexual couple who never traveled abroad, thus providing the first molecular evidence of autochthonous horizontal transmission of this lineage of major global importance. Also, three phylogenetic clusters of strains
recovered from a total of 18.3% of the cohort were uncovered. Their close genetic relatedness suggests they
were recovered from patients who probably took part in the same chain of viral spread. In conjunction with our
previous surveys from inner Rio de Janeiro, these results suggest that although small cities harbor unique
molecular features of HIV-1 infection, they also clearly reflect and may rapidly absorb the diversity recorded in
large urban centers. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | |
| dc.rights | open access | |
| dc.subject | AG - vírus da imunodeficiência humana tipo 1 | |
| dc.subject | Clusters de transmissão | |
| dc.subject | Epidemiologia molecular | |
| dc.subject | Brasil | |
| dc.subject | AG - human immunodeficiency virus type 1 | |
| dc.subject | Molecular epidemiology | |
| dc.subject | Transmission clusters | |
| dc.subject | Brazil | |
| dc.title | Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil | |
| dc.type | Article | |
