Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction

dc.creatorMenezes, Ana Paula de Oliveira
dc.creatorAzevedo, Jailton
dc.creatorLeite, Mariela C
dc.creatorCampos, Leila Carvalho
dc.creatorCunha, Marcelo
dc.creatorCarvalho, Maria da Gloria S
dc.creatorReis, Mitermayer Galvão dos
dc.creatorKo, Albert Icksang
dc.creatorWeinberger, Daniel M
dc.creatorRibeiro, Guilherme de Sousa
dc.creatorReis, Joice Neves
dc.date2016-03-04T18:58:18Z
dc.date2016-03-04T18:58:18Z
dc.date2016
dc.date.accessioned2023-09-26T21:05:21Z
dc.date.available2023-09-26T21:05:21Z
dc.identifierMENEZES, A. P. O. Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction. Vaccine, v. 34, n. 6, p. 791-797, 2016.
dc.identifier0264-410X
dc.identifierdx.doi.org/10.1016/j.vaccine.2015.12.042
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/13029
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868957
dc.descriptiontInformation on pneumococcal carriage in the pre-vaccine period is essential to predict and assess theimpact of PCV in settings where disease surveillance is particularly difficult. Therefore, we present dataon pneumococcal carriage before the introduction of the 10-valent-pneumococcal conjugate vaccine(PCV10) in Brazil. We conducted a prospective study on a cohort of 203 children aged <5 years old,randomly selected in an urban community located in the periphery of the city of Salvador, Brazil andfollowed them from January/2008 to January/2009. Nasopharyngeal swabs were collected from eachchild at four times. In total, 721 swabs were collected, yielding a pneumococcal carriage prevalence of55% (n = 398). In multivariate analyses, the variables associated with carriage were having contact withthree or more children <2 years old (OR, 2.00; 95% CI 1.33–2.89) and living in a house with an averageof 3 residents per room (OR, 1.77; 95% CI 1.05–3.10). Also, white participants were more likely to beprotected from colonization (OR, 0.52; 95% CI 0.29–0.93), and prevalence of carriage varied over time,with lower prevalence occurring from February to June (OR, 0.53; 95% CI 0.37–0.78) compared to Julyto January. Contact with children under 2 years of age and living in crowded housing also were associ-ated with colonization by highly invasive serotypes, although this relationship was not significant. Themost prevalent vaccine serotypes were 6A/B (25.4%), 19F (10.1%) and 14 (9.0%), while the most preva-lent non-vaccine serotypes were 16F (4.8%), 15B/C (4.5%) and 6C/D (3.5%). Overall, 38.4% (153/398) ofthe isolates were non-susceptible to penicillin, and of those, 73.8% (113/153) were non-susceptible totrimethoprim/sulfamethoxazole. Colonization rate by PCV10 serotypes was 52.2%. Routine PCV10 vacci-nation can lead to significant changes in pneumococcal serotypes found in NP colonization, indicating aneed for continued monitoring, especially in crowded settings, as occurs in Brazil’s slums.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectChildren
dc.subjectNasopharyngeal carriage
dc.subjectStreptococcus pneumoniae
dc.subjectSerotypes
dc.subjectPCV10-vaccine
dc.titleNasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction
dc.typeArticle


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