Conjoined twins: a worldwide collaborative epidemiological study of the International Clearinghouse for Birth Defects Surveillance and Research

dc.creatorMutchinick, Osvaldo M.
dc.creatorLuna-Muñoz, Leonora
dc.creatorAmar, Emmanuelle
dc.creatorBakker, Marian K.
dc.creatorClementi, Maurizio
dc.creatorCocchi, Guido
dc.creatorDutra, Maria da Graça
dc.creatorFeldkamp, Marcia L.
dc.creatorLandau, Danielle
dc.creatorLeoncini, Emanuele
dc.creatorLi, Zhu
dc.creatorLowry, Brian
dc.creatorMarengo, Lisa K.
dc.creatorMartínez-Frías, María-Luisa
dc.creatorMastroiacovo, Pierpaolo
dc.creatorMétneki, Julia
dc.creatorMorgan, Margery
dc.creatorPierini, Anna
dc.creatorRissman, Anke
dc.creatorRitvanen, Annukka
dc.creatorScarano, Gioacchino
dc.creatorSiffel, Csaba
dc.creatorSzabova, Elena
dc.creatorArteaga-Vázquez, Jazmín
dc.date2020-04-02T18:21:55Z
dc.date2020-04-02T18:21:55Z
dc.date2011
dc.date.accessioned2023-09-26T21:05:10Z
dc.date.available2023-09-26T21:05:10Z
dc.identifierMUTCHINICK, Oswaldo M. et al. Conjoined Twins: A Worldwide Collaborative Epidemiological Study of the International Clearinghouse for Birth Defects Surveillance and Research. Am J Med Genet C Semin Med Genet., v. 157C, n. 4, p. 274-287, Nov. 2011.
dc.identifier1552-4868
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40621
dc.identifier10.1002/ajmg.c.30321
dc.identifier1552-4876
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868905
dc.descriptionConjoined twins (CT) are a very rare developmental accident of uncertain etiology. Prevalence has been previously estimated to be 1 in 50,000 to 1 in 100,000 births. The process by which monozygotic twins do not fully separate but form CT is not well understood. The purpose of the present study was to analyze diverse epidemiological aspects of CT, including the different variables listed in the Introduction Section of this issue of the Journal. The study was made possible using the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR) structure. This multicenter worldwide research includes the largest sample of CT ever studied. A total of 383 carefully reviewed sets of CT obtained from 26,138,837 births reported by 21 Clearinghouse Surveillance Programs (SP) were included in the analysis. Total prevalence was 1.47 per 100,000 births (95% CI: 1.32-1.62). Salient findings including an evident variation in prevalence among SPs: a marked variation in the type of pregnancy outcome, a similarity in the proportion of CT types among programs: a significant female predominance in CT: particularly of the thoracopagus type and a significant male predominance in parapagus and parasitic types: significant differences in prevalence by ethnicity and an apparent increasing prevalence trend in South American countries. No genetic, environmental or demographic significant associated factors were identified. Further work in epidemiology and molecular research is necessary to understand the etiology and pathogenesis involved in the development of this fascinating phenomenon of nature.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley 12 Months
dc.rightsrestricted access
dc.subjectGêmeos siameses
dc.subjectEpidemiologia
dc.subjectEstudo multicêntrico
dc.subjectConjoined twins
dc.subjectEpidemiology
dc.subjectMulticentric study
dc.subjectICBDSR
dc.titleConjoined twins: a worldwide collaborative epidemiological study of the International Clearinghouse for Birth Defects Surveillance and Research
dc.typeArticle


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