Streptococcus pneumoniae Serotypes 9 and 14 Circulating in Brazil over a 23-Year Period Prior to Introduction of the 10-Valent Pneumococcal Conjugate Vaccine: Role of International Clones in the Evolution of Antimicrobial Resistance and Description of a Novel Genotype

dc.creatorPinto, Tatiana C. A.
dc.creatorKegele, Fabíola C. O.
dc.creatorDias, Cícero A. G.
dc.creatorBarros, Rosana R.
dc.creatorPeralta, José M.
dc.creatorMerquior, Vânia L. C.
dc.creatorCarvalho, Maria da Gloria
dc.creatorChochua, Sopio
dc.creatorHawkins, Paulina
dc.creatorMcGee, Lesley
dc.creatorTeixeira, Lucia M.
dc.date2021-02-05T20:14:03Z
dc.date2021-02-05T20:14:03Z
dc.date2016
dc.date.accessioned2023-09-26T21:04:57Z
dc.date.available2023-09-26T21:04:57Z
dc.identifierPINTO, Tatiana C. A. et al. Streptococcus pneumoniae Serotypes 9 and 14 Circulating in Brazil over a 23-Year Period Prior to Introduction of the 10-Valent Pneumococcal Conjugate Vaccine: Role of International Clones in the Evolution of Antimicrobial Resistance and Description of a Novel Genotype. Antimicrobial Agents and Chemotherapy, v. 60, n. 11, p. 6664-6672, 2016.
dc.identifier0066-4804
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/45975
dc.identifier10.1128/AAC.00673-16
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868849
dc.descriptionThis study was supported in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ).
dc.descriptionAntimicrobial-resistant pneumococcal strains have been detected worldwide since the 1960s. In Brazil, the first penicillin-nonsusceptible pneumococci (PNSP) were reported in the 1980s, and their emergence and dissemination have been mainly attributed to serogroup 9 and serotype 14 strains, especially those highly related to recognized international clones. In the present study, antimicrobial susceptibility testing and multilocus sequence typing were performed on 315 pneumococcal isolates belonging to serogroup 9 (n = 99) or serotype 14 (n = 216), recovered from patients or asymptomatic carriers between 1988 and 2011 in Brazil, in order to trace changes in antimicrobial resistance and genotypes prior to the full introduction of the pneumococcal conjugate vaccine in the country. Over the 23-year study period, the PNSP levels increased, and four clonal complexes (CC156, CC66, CC15, and CC5401) have played important roles in the evolution and dissemination of pneumococcal isolates belonging to serogroup 9 and serotype 14, as well as in the emergence of antimicrobial resistance, in the pre-pneumococcal-vaccination era. The earliest PNSP strains detected in this study belonged to serotype 9N/ST66 and were single locus variants of the international clone Tennessee14-18 ST67 (CC66). The first serotype 14 PNSP isolates were identified in 1990 and were related to the England14-9 ST9 (CC15) clone. Serotype 14 PNSP variants of the Spain9V-3 ST156 clone with elevated penicillin MICs and nonsusceptibility to other beta-lactams were detected in 1995 and showed an increasing trend over the years. The results also indicated that introduction of ST156 in our region was preceded by the emergence of trimethoprim-sulfamethoxazole resistance and by the dissemination of ST162. In addition to the presence of successful international clones, a novel regional serotype 14 genotype (CC5401) has emerged in 1996.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society for Microbiology
dc.rightsopen access
dc.subjectAnti-Bacterial Agents / pharmacology
dc.subjectAsymptomatic Diseases Brazil / epidemiology
dc.subjectClone Cells
dc.subjectDrug Resistance, Multiple, Bacterial / genetics
dc.subjectHistory, 21st Century
dc.subjectHistory, 20th Century
dc.subjectEpidemiological Monitoring Europe / epidemiology
dc.subjectPhylogeography
dc.subjectPhylogeny
dc.subjectPenicillins / pharmacology
dc.subjectPenicillin Resistance / genetics
dc.subjectMultilocus Sequence Typing
dc.subjectMicrobial Sensitivity Tests
dc.subjectHumans
dc.subjectIncidence
dc.subjectPneumococcal Infections / epidemiology
dc.subjectPneumococcal Infections / drug therapy
dc.subjectPneumococcal Infections / history
dc.subjectPneumococcal Infections / microbiology
dc.subjectPneumococcal Vaccines
dc.subjectSerogroup
dc.subjectStreptococcus pneumoniae / classification
dc.subjectStreptococcus pneumoniae / drug effects
dc.subjectStreptococcus pneumoniae / genetics
dc.subjectStreptococcus pneumoniae / isolation & purification
dc.subjectUnited States / epidemiology
dc.subjectTrimethoprim, Sulfamethoxazole Drug Combination / pharmacology
dc.titleStreptococcus pneumoniae Serotypes 9 and 14 Circulating in Brazil over a 23-Year Period Prior to Introduction of the 10-Valent Pneumococcal Conjugate Vaccine: Role of International Clones in the Evolution of Antimicrobial Resistance and Description of a Novel Genotype
dc.typeArticle


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