Free radical production by azomethine H: Effects on pancreatic and hepatic tissues

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorNovelli, E. L B
dc.creatorSilva, A. M M
dc.creatorMonteiro, J. P.
dc.creatorSacomani, L. B.
dc.creatorNovellif, J. L V B
dc.date2014-05-27T11:18:14Z
dc.date2016-10-25T18:14:30Z
dc.date2014-05-27T11:18:14Z
dc.date2016-10-25T18:14:30Z
dc.date1997-06-25
dc.date.accessioned2017-04-06T00:49:45Z
dc.date.available2017-04-06T00:49:45Z
dc.identifierFree Radical Research, v. 26, n. 4, p. 319-324, 1997.
dc.identifier1071-5762
dc.identifierhttp://hdl.handle.net/11449/65129
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65129
dc.identifier10.3109/10715769709097811
dc.identifierWOS:A1997WY52200004
dc.identifier2-s2.0-0030926689
dc.identifierhttp://dx.doi.org/10.3109/10715769709097811
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886880
dc.descriptionThe antimalarial properties of azomethine H represent the basis for its use as a chemotherapeutic agent. This work was carried out in order to verify the biological side effects of azomethine H and to clarify the contribution of reactive oxygen species (ROS) in this process. It was shown that azomethine H increased serum activities of amylase, alanine transaminase (ALT) and the TEARS concentrations, in rats. No changes were observed in glutathione peroxidase and catalase activities. The drug-induced tissue damage might be due to superoxide radicals (O-2(.-)), since Cu-Zn superoxide dismutase activities were increased by azomethine I-I treatment. This study allows tentative conclusions to be drawn regarding which reactive oxygen metabolites play a role in azomethine H activity. We concluded that (O-2(.-)) maybe produced as a mediator of azomethine H action.
dc.languageeng
dc.relationFree Radical Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAzomethine H
dc.subjectCu-Zn superoxide dismutase
dc.subjectGlutathione peroxidase
dc.subjectSuperoxide radical
dc.subjectToxicity
dc.subjectalanine aminotransferase
dc.subjectamylase
dc.subjectantimalarial agent
dc.subjectazomethine h
dc.subjectcatalase
dc.subjectcopper zinc superoxide dismutase
dc.subjectfree radical
dc.subjectglutathione peroxidase
dc.subjectreactive oxygen metabolite
dc.subjectsuperoxide
dc.subjectthiobarbituric acid reactive substance
dc.subjectunclassified drug
dc.subjectalanine aminotransferase blood level
dc.subjectamylase blood level
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectenzyme activity
dc.subjectintraperitoneal drug administration
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjecttissue injury
dc.subjectAlanine Transaminase
dc.subjectAmylases
dc.subjectAnimals
dc.subjectAntimalarials
dc.subjectCatalase
dc.subjectDose-Response Relationship, Drug
dc.subjectFree Radicals
dc.subjectGlutathione Peroxidase
dc.subjectLiver
dc.subjectMale
dc.subjectNaphthalenesulfonates
dc.subjectPancreas
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReactive Oxygen Species
dc.subjectSuperoxide Dismutase
dc.subjectSuperoxides
dc.subjectThiobarbituric Acid Reactive Substances
dc.subjectThiosemicarbazones
dc.subjectAnimalia
dc.titleFree radical production by azomethine H: Effects on pancreatic and hepatic tissues
dc.typeOtro


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