Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model

dc.creatorSouza, Márcia Maria de
dc.creatorParaná, Raymundo
dc.creatorTrépo, Christian
dc.creatorBarbosa Junior, Aryon de Almeida
dc.creatorOliveira, Irismar Reis de
dc.creatorAndrade, Zilton de Araújo
dc.date2013-02-04T21:04:11Z
dc.date2013-02-04T21:04:11Z
dc.date2001
dc.date.accessioned2023-09-26T21:04:46Z
dc.date.available2023-09-26T21:04:46Z
dc.identifierSOUZA, M. M. de et al. Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model. Memórias do Instituto Oswaldo Cruz, v. 96, n. 3, p. 343-348, apr. 2001.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6292
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868799
dc.descriptionInterferon-alpha is used in antiviral therapy in humans, mainly for viral hepatitis B and C. An anti-fibrotic effect of interferon has been postulated even in the absence of anti-viral response, which suggests that interferon directly inhibits fibrogenesis. Rats infected with the helminth Capillaria hepatica regularly develop diffuse septal fibrosis of the liver, which terminates in cirrhosis 40 days after inoculation. The aim of this study was to test the anti-fibrotic effect of interferon in this experimental model. Evaluation of fibrosis was made by three separate methods: semi-quantitative histology, computerized morphometry and hydroxyproline measurements. Treatment with interferon-alpha proved to inhibit the development of fibrosis in this model, especially when doses of 500,000 and 800,000 IU were used for 60 days. Besides confirming the anti-fibrotic potential of interferon-alpha on a non-viral new experimental model of hepatic fibrosis, a clear-cut dose-dependent effect was observed.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectInterferon-a
dc.subjectHepatic fibrosis
dc.subjectCapillaria hepatica
dc.subjectCirrose Hepática
dc.subjectExperimental/quimioterapia
dc.subjectInterferon alfa/uso terapêutico
dc.subjectAntivirais/uso terapêutico
dc.subjectModelos Animais
dc.subjectModelos Animais de Doenças
dc.subjectCapillaria
dc.subjectCirrose Hepática Experimental/patologia
dc.subjectHidroxiprolina/análise
dc.subjectFígado/química
dc.subjectRatos Wistar
dc.subjectEstudos de Casos e Controles
dc.subjectAnimais
dc.subjectRatos
dc.subjectMasculino
dc.subjectFeminino
dc.titleEffect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model
dc.typeArticle


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