Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins

dc.creatorCavada, Benildo Sousa
dc.creatorBessa, Theolis Costa Barbosa
dc.creatorArruda, Sérgio Marcos
dc.creatorGrangeiro, Thalles Barbosa
dc.creatorBarral Netto, Manoel
dc.date2014-03-24T17:08:26Z
dc.date2014-03-24T17:08:26Z
dc.date2001
dc.date.accessioned2023-09-26T21:04:23Z
dc.date.available2023-09-26T21:04:23Z
dc.identifierCAVADA, B. et al. Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins. Current Protein and Peptide Science, v. 2, p. 123-135, 2001.
dc.identifier1389-2037
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7439
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868699
dc.descriptionSignificant differences in function have been observed among lectins structurally similar to concanavalin A, but their high homology with this widely used lectin has kept them in obscurity. The observation of large differences in the potency of many of these Diocleinae lectins as stimulators of Interferon-g production by human peripheral blood mononuclear cells has lead to a major effort to unravel their chemical structure and biological activity. Modeling studies of some of these lectins reveal conformational changes in side chains of some residues involved in the carbohydrate-binding site, with possible effects on the ability of these proteins to recognize specific carbohydrate structures. Additionally, all them constitute in fact a mixture of isolectins, which in different proportions could lead to diverse effects. The present review of the biological actions of Diocleinae lectins includes several in vitro and in vivo immunological findings, as well as their effects on insect growth and reproduction. In these systems Diocleinae lectins proved to be quite diverse in their potency. Such diversity in the biological activity of highly related proteins recalls the origin of the name protein: like Proteus, the capability of assuming various forms is the essential feature of this class of molecules.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBentham Science Publishers Ltd.
dc.rightsopen access
dc.subjectLectinas/química
dc.subjectLectinas/farmacologia
dc.subjectSequência de Aminoácidos
dc.subjectAnimais
dc.subjectBiotecnologia
dc.subjectFabaceae/química
dc.subjectFabaceae/genética
dc.subjectHumanos
dc.subjectLectinas/genética
dc.subjectDados de Sequência Molecular
dc.subjectHomologia de Sequência de Aminoácidos
dc.subjectRelação Estrutura-Atividade
dc.titleRevisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins
dc.typeArticle


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