H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis

dc.creatorSouza, Thiago Moreno L.
dc.creatorSalluh, Jorge I. F.
dc.creatorBozza, Fernando A.
dc.creatorMesquita, Milene
dc.creatorSoares, Márcio
dc.creatorMotta, Fernando C.
dc.creatorPitrowsky, Melissa Tassano
dc.creatorOliveira, Maria de Lourdes
dc.creatorMishin, Vasiliy P.
dc.creatorGubareva, Larissa V.
dc.creatorWhitney, Anne
dc.creatorRocco, Sandra Amaral
dc.creatorGonçalves, Vânia Maria C.
dc.creatorMarques, Venceslaine Prado
dc.creatorVelasco, Eduardo
dc.creatorSiqueira, Marilda Agudo Mendonça Teixeira de
dc.date2018-03-13T17:30:33Z
dc.date2018-03-13T17:30:33Z
dc.date2010
dc.date.accessioned2023-09-26T21:04:22Z
dc.date.available2023-09-26T21:04:22Z
dc.identifierSOUZA, Thiago Moreno L. et al. H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis. PLoS ONE, v. 5, n. 11, p.1-10, Nov. 2010.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25292
dc.identifier10.1371/journal.pone.0014158
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868691
dc.descriptionBackground: The novel influenza A pandemic virus (H1N1pdm) caused considerable morbidity and mortality worldwide in 2009. The aim of the present study was to evaluate the clinical course, duration of viral shedding, H1N1pdm evolution and emergence of antiviral resistance in hospitalized cancer patients with severe H1N1pdm infections during the winter of 2009 in Brazil. Methods: We performed a prospective single-center cohort study in a cancer center in Rio de Janeiro, Brazil. Hospitalized patients with cancer and a confirmed diagnosis of influenza A H1N1pdm were evaluated. The main outcome measures in this study were in-hospital mortality, duration of viral shedding, viral persistence and both functional and molecular analyses of H1N1pdm susceptibility to oseltamivir. Results: A total of 44 hospitalized patients with suspected influenza-like illness were screened. A total of 24 had diagnosed H1N1pdm infections. The overall hospital mortality in our cohort was 21%. Thirteen (54%) patients required intensive care. The median age of the studied cohort was 14.5 years (3–69 years). Eighteen (75%) patients had received chemotherapy in the previous month, and 14 were neutropenic at the onset of influenza. A total of 10 patients were evaluated for their duration of viral shedding, and 5 (50%) displayed prolonged viral shedding (median 23, range = 11–63 days); however, this was not associated with the emergence of a resistant H1N1pdm virus. Viral evolution was observed in sequentially collected samples. Conclusions: Prolonged influenza A H1N1pdm shedding was observed in cancer patients. However, oseltamivir resistance was not detected. Taken together, our data suggest that severely ill cancer patients may constitute a pandemic virus reservoir with major implications for viral propagation.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectPacientes com câncer
dc.subjectHospitalizados
dc.subjectAnálise viral
dc.subjectEvolução clínica
dc.subjectVírus pandêmico da gripe A
dc.subjectCancer Patients
dc.subjectHospitalized
dc.subjectInfluenza A pandemic virus
dc.subjectClinical Evolution
dc.subjectViral Analysis
dc.titleH1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis
dc.typeArticle


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