Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil

dc.creatorOliveira, S. M. V. L. de
dc.creatorPaniago, A. M. M.
dc.creatorBonecini-Almeida, M. G.
dc.creatorBertoni, Neilane
dc.creatorStabile, A. C.
dc.creatorCunha, R. V. da
dc.creatorOliveira, O. A. de
dc.creatorDruzian, A. F.
dc.creatorNegri, A. C.
dc.creatorAndreotti, R.
dc.date2019-12-03T13:17:46Z
dc.date2019-12-03T13:17:46Z
dc.date2010
dc.date.accessioned2023-09-26T21:04:00Z
dc.date.available2023-09-26T21:04:00Z
dc.identifierOLIVEIRA, S. M. V. L. de et al. Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 16, n. 2, p. 285-297, 2010.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/37534
dc.identifier10.1590/S1678-91992010000200010
dc.identifier1678-9199
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868594
dc.descriptionA cross-sectional study on HIV/AIDS was carried out in 108 outpatients from the university hospital of the Federal University of Mato Grosso do Sul, Campo Grande, Brazil, from July to December 2008, to investigate latent tuberculosis infection using the tuberculin skin test (TST). The prevalence of positive results was 13.9%. The CD4+ T cell count (p = 0.091) and the diagnosis time (p = 0.010) were statistically significant when compared with TST positivity. In the cohort of HIV/AIDS patients who had latent tuberculosisinfection, the median diagnosis time was eight years. Undetectable viral load presented significant association (p = 0.046) with tuberculosis infection. The fact that numerous individuals with HIV/AIDS infection presented a negative reaction to the tuberculin skin test is probably related to alterations in the cellular immune response induced by HIV infection. The tuberculin test is a useful tool for the detection of latent tuberculosis infection and should be performed in all HIV/AIDS individuals at the time of the diagnosis and on a yearly basis, if negative. Both the early identification of the tuberculosis infection by the tuberculin skin test at the moment of immunological restoration and chemoprophylaxis in infected individuals are mechanisms to control HIV/AIDS and tuberculosis coinfection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMC
dc.rightsopen access
dc.subjectTuberculin skin test
dc.subjectAcquired immunodeficiency syndrome
dc.subjectCD4/CD8 cell count
dc.titleTuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil
dc.typeArticle


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