Vitamin D, D-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study

dc.creatorMusselwhite, Laura W
dc.creatorAndrade, Bruno de Bezerril
dc.creatorEllenberg, Susan S
dc.creatorTierney, Ann
dc.creatorZamudio, Pablo F. Belaunzaran
dc.creatorRupert, Adam
dc.creatorLederman, Michael M
dc.creatorSanne, Ian
dc.creatorSierra Madero, Juan G
dc.creatorSereti, Irini
dc.date2016-12-05T17:01:32Z
dc.date2016-12-05T17:01:32Z
dc.date2016
dc.date.accessioned2023-09-26T21:03:45Z
dc.date.available2023-09-26T21:03:45Z
dc.identifierMUSSELWHITE, L.W. et al. Vitamin D, D-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study. EBio Medicine, v. 4, p. 115–123, 2016.
dc.identifier2352-3964
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16424
dc.identifier10.1016/j.ebiom.2016.01.016
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868527
dc.descriptionIntramural Research Program of the National Institute of Allergy and Infectious Diseases of the National Institutes of Health the National Cancer Institute
dc.descriptionTo determine the immunological profile most important for IRIS prediction, we evaluated 20 baseline plasma biomarkers in Acquired Immunodeficiency Syndrome (AIDS) patients initiating antiretroviral therapy (ART). Patients were enrolled in a randomized, placebo-controlled ART initiation trial in South Africa and Mexico to test whether maraviroc could prevent IRIS. Participants were classified prospectively as having IRIS within 6 months of ART initiation. Twenty plasma biomarkers were measured at study enrollment for 267 participants. Biomarkers were tested for predicting IRIS with adjustment for covariates chosen through forward stepwise selection. Sixty-two participants developed IRIS and of these 19 were tuberculosis (TB)-IRIS. Baseline levels of vitamin D and higher d-dimer, interferon gamma (IFNγ), and sCD14 were independently associated with risk of IRIS in multivariate analyses. TB-IRIS cases exhibited a distinct biosignature from IRIS related to other pathogens, with increased levels of C-reactive protein (CRP), sCD14, IFNγ, and lower levels of Hb that could be captured by a composite risk score. Elevated markers of Type 1 T helper (Th1) response, monocyte activation, coagulation and low vitamin D were independently associated with IRIS risk. Interventions that decrease immune activation and increase vitamin D levels warrant further study.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectIRIS
dc.subjectHIV
dc.subjectBiomarcador
dc.subjectVitamina D
dc.subjectCitocina inflamatória
dc.subjectIRIS
dc.subjectHIV
dc.subjectBiomarker
dc.subjectVitamin D
dc.subjectD-Dimer
dc.subjectInflammatory cytokine
dc.titleVitamin D, D-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study
dc.typeArticle


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