Increased sensitivity of NS1 ELISA by heat dissociation in acute dengue 4 cases

dc.creatorBuonora, Sibelle Nogueira
dc.creatorSantos, Flávia Barreto dos
dc.creatorDaumas, Regina Paiva
dc.creatorPassos, Sonia Regina Lambert
dc.creatorSilva, Manoela Heringer da
dc.creatorLima, Monique Rocha de
dc.creatorNogueira, Rita Maria Ribeiro
dc.date2018-02-20T11:23:49Z
dc.date2018-02-20T11:23:49Z
dc.date2017
dc.date.accessioned2023-09-26T21:03:17Z
dc.date.available2023-09-26T21:03:17Z
dc.identifierBUONORA, Sibelle Nogueira; et al. Increased sensitivity of NS1 ELISA by heat dissociation in acute dengue 4 cases. BMC Infectious Diseases, v.17:204, 5p, 2017.
dc.identifier1471-2334
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/24871
dc.identifier10.1186/s12879-017-2306-z
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868402
dc.descriptionDengue is an acute febrile illness considered the major arboviral disease in terms of morbidity, mortality, economic impact and dissemination worldwide. Brazil accounts for the highest notification rate, with circulation of all four dengue serotypes. The NS1 antigen is a dengue highly conserved specific soluble glycoprotein essential for viral replication and viability that can be detected 0 to 18 days from the onset of fever (peak first 3 days). It induces a strong humoral response and is known as a complement-fixing antigen. Lower NS1 test sensitivity occurs in secondary dengue infections probably due to immune complex formation impairing antigen detection by ELISA.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.rightsopen access
dc.subjectEnsaio de Imunoadsorção Enzimática
dc.subjectPrecisão
dc.subjectDiagnóstico de Dengue
dc.subjectDissociação do complexo imunitário
dc.subjectNS1 ELISA
dc.subjectAccuracy
dc.subjectDengue diagnosis
dc.subjectImmune complex dissociation
dc.subjectDENV-4
dc.titleIncreased sensitivity of NS1 ELISA by heat dissociation in acute dengue 4 cases
dc.typeArticle


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