Multifactorial control of water and saline intake: Role of α2-adrenoceptors

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDe-Luca, L. A.
dc.creatorMenani, José Vanderlei
dc.date2014-05-27T11:18:13Z
dc.date2016-10-25T18:14:25Z
dc.date2014-05-27T11:18:13Z
dc.date2016-10-25T18:14:25Z
dc.date1997-04-01
dc.date.accessioned2017-04-06T00:49:25Z
dc.date.available2017-04-06T00:49:25Z
dc.identifierBrazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 497-502, 1997.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/65080
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65080
dc.identifier10.1590/S0100-879X1997000400011
dc.identifierS0100-879X1997000400011
dc.identifierWOS:A1997WT02000011
dc.identifier2-s2.0-0031110231.pdf
dc.identifier2-s2.0-0031110231
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1997000400011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886838
dc.descriptionWater and saline intake is controlled by several mechanisms activated during dehydration. Some mechanisms, such as the production of angiotensin II and unloading of cardiovascular receptors, activate both behaviors, while others, such as the increase in blood osmolality or sodium concentration, activate water, but inhibit saline intake. Aldosterone probably activates only saline intake. Clonidine, anα2-adrenergic agonist, inhibits water and saline intake induced by these mechanisms. One model to describe the interactions between these multiple mechanisms is a wire-block diagram, where the brain circuit that controls each intake is represented by a summing point of its respective inhibiting and activating factors. The α2-adrenoceptors constitute an inhibitory factor common to both summing points.
dc.languageeng
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectα2-Adrenergic agonist
dc.subjectClonidine
dc.subjectDehydration
dc.subjectNoradrenaline
dc.subjectSodium intake
dc.subjectWater intake
dc.subjectalpha 2 adrenergic receptor
dc.subjectalpha adrenergic receptor stimulating agent
dc.subjectclonidine
dc.subjectnoradrenalin
dc.subjectsodium chloride
dc.subjectanimal
dc.subjectdehydration
dc.subjectdrinking
dc.subjectdrug effect
dc.subjectmetabolism
dc.subjectphysiology
dc.subjectrenin angiotensin aldosterone system
dc.subjectreview
dc.subjectAdrenergic alpha-Agonists
dc.subjectAnimals
dc.subjectDrinking
dc.subjectNorepinephrine
dc.subjectReceptors, Adrenergic, alpha-2
dc.subjectRenin-Angiotensin System
dc.subjectSodium Chloride
dc.titleMultifactorial control of water and saline intake: Role of α2-adrenoceptors
dc.typeOtro


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