CD40 signaling induces reciprocal outcomes in Leishmania-infected macrophages; roles of host genotype and cytokine milieu

dc.creatorNunes, Marise P.
dc.creatorCysne-Finkelstein, Lea
dc.creatorMonteiro, Bruna C.
dc.creatorSouza, Daniel M. de
dc.creatorGomes, Nitza A.
dc.creatorReis, George A. dos
dc.date2019-12-17T16:14:32Z
dc.date2019-12-17T16:14:32Z
dc.date2005
dc.date.accessioned2023-09-26T21:02:45Z
dc.date.available2023-09-26T21:02:45Z
dc.identifierNUNES, Marise P. et al. CD40 signaling induces reciprocal outcomes in Leishmania-infected macrophages; roles of host genotype and cytokine milieu. Microbes and Infection, v. 7, p. 78-85, 2005.
dc.identifier1286-4579
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/38659
dc.identifier10.1016/j.micinf.2004.08.022
dc.identifier1769-714X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868254
dc.descriptionWe investigated the influence of CD40-CD40 ligand-mediated signaling on induction of microbicidal activity against Leishmania major in macrophages from resistant (B6) and susceptible (BALB) mouse strains. CD40 engagement induced leishmanicidal activity in resistant macrophages, but increased parasite replication in susceptible macrophages. CD40 engagement induced comparable TNF-alpha production in macrophages from both strains. However, increased IL-10 production was restricted to susceptible macrophages. Increased parasite replication in susceptible macrophages was prevented by a neutralizing anti-IL-10 antibody. In the presence of IFN-gamma, CD40 engagement induced Leishmania killing by macrophages from both strains. Therefore, the outcome of CD40 signaling on effector responses against L. major depends on host genotype and the cytokine milieu, and a source of IFN-gamma is required for a protective response.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectLeishmania major
dc.subjectCélulas T CD4 +
dc.subjectMacrófago
dc.subjectInterleucina
dc.subjectAntígenos CD40
dc.subjectLigante de CD40
dc.subjectLeishmania major
dc.subjectCD40
dc.subjectMacrophage
dc.subjectCD40 ligand
dc.subjectIFN-y
dc.subjectCD4+ T cells
dc.subjectAntígenos CD40
dc.subjectLigante de CD40
dc.titleCD40 signaling induces reciprocal outcomes in Leishmania-infected macrophages; roles of host genotype and cytokine milieu
dc.typeArticle


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