Efeito do lisinopril sobre parametros cardiacos e mortalidade no infarto experimental em ratos

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorZornoff, Leonardo Antonio Mamede
dc.creatorPaiva, Sergio Alberto Rupp de
dc.creatorMatsubara, Beatriz Bojikian
dc.creatorMatsubara, Luiz Shiguero
dc.creatorTucci, Paulo J. F.
dc.creatorSpadaro, Joel
dc.date2014-05-27T11:18:12Z
dc.date2016-10-25T18:14:22Z
dc.date2014-05-27T11:18:12Z
dc.date2016-10-25T18:14:22Z
dc.date1997-03-01
dc.date.accessioned2017-04-06T00:49:18Z
dc.date.available2017-04-06T00:49:18Z
dc.identifierArquivos Brasileiros de Cardiologia, v. 68, n. 3, p. 175-179, 1997.
dc.identifier0066-782X
dc.identifierhttp://hdl.handle.net/11449/65065
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65065
dc.identifier2-s2.0-0030988181.pdf
dc.identifier2-s2.0-0030988181
dc.identifierhttp://www.arquivosonline.com.br/pesquisartigos/Pdfs/1997/V68N3/68030007.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886824
dc.descriptionPurpose: To analyse the effect of early (<24 h) administration of lisinopril on ventricular remodeling and mortality after myocardial infarction (MI) in rats. Methods: Wistar rats weighing 200-250 g were submitted to ligation of the left coronary artery (LCA) and divided into three groups: SHAM (S, n = 9); infarcted and lisinopril (20 mg/kg/day) treated rats (L, n = 38); infarcted and non-treated animals (NT, n = 24). Three months later, the cardiac function was studied in isolated heart preparation according to the Langendorff technique. Starling curves were constructed using fluid injection in the left ventricular balloon, which permitted to alter the diastolic pressure range from 0 to 30 mmHg by means of pressure increments of 5 mmHg. Body weight (BW), right ventricular weight (RVW), and RVW/BW were also determined. Results: Three months after the surgery, the comparative mortality rate among groups was: S = 0; L = 34.4% and NT = 54.4% (p > 0.05, for L vs NT). In infarctions < 40% of the left ventricle (LV), the RVW/BW relation was S = L < NT (p < 0.05); the left ventricular systolic pressure was S > L > NT (p < 0.05). In infarctions > 40% of LV, the RVW/BW relation was S < L = NT (p < 0.05). For the Starling curves, the results were S > L > NT (p < 0.05). Conclusion: In our model lisinopril did not interfere with post-infarction mortality of rats, although decreasing the mortality risk in 49%, in the treated group. The drug also altered the remodeling process, preventing hypertrophy and systolic dysfunction after MI, mainly in infarctions < 40% of LV.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languagepor
dc.relationArquivos Brasileiros de Cardiologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectlisinopril
dc.subjectmyocardial infarction
dc.subjectrat
dc.subjectdipeptidyl carboxypeptidase inhibitor
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectblood pressure
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectheart infarction
dc.subjectheart ventricle remodeling
dc.subjectmortality
dc.subjectnonhuman
dc.subjectanalysis of variance
dc.subjectanimal
dc.subjectbody weight
dc.subjectcardiomegaly
dc.subjectheart contraction
dc.subjectheart left ventricle function
dc.subjectmale
dc.subjectnonparametric test
dc.subjectorgan size
dc.subjectWistar rat
dc.subjectAnalysis of Variance
dc.subjectAngiotensin-Converting Enzyme Inhibitors
dc.subjectAnimals
dc.subjectBlood Pressure
dc.subjectBody Weight
dc.subjectCardiomegaly
dc.subjectLisinopril
dc.subjectMale
dc.subjectMyocardial Contraction
dc.subjectMyocardial Infarction
dc.subjectOrgan Size
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStatistics, Nonparametric
dc.subjectVentricular Function, Left
dc.titleEfeito do lisinopril sobre parametros cardiacos e mortalidade no infarto experimental em ratos
dc.typeOtro


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