The effect of removing potentially infectious dogs on the numbers of Canine Leishmania infantum Infections in an endemic area with high transmission rates

dc.creatorGrimaldi Jr., Gabriel
dc.creatorTeva, Antonio
dc.creatorSantos, Claudiney B.
dc.creatorFerreira, Adelson L.
dc.creatorFalqueto, Aloísio
dc.date2017-04-17T12:57:17Z
dc.date2017-04-17T12:57:17Z
dc.date2012
dc.date.accessioned2023-09-26T21:02:37Z
dc.date.available2023-09-26T21:02:37Z
dc.identifierGRIMALDI JR., Gabriel; TEVA, Antonio; SANTOS, Claudiney B.; FERREIRA, Adelson L.; FALQUETO, Aloísio. the effect of removing potentially infectious dogs on the numbers of Canine Leishmania infantum infections in an endemic area with high transmission rates. Am. J. Trop. Med. Hyg., San Francisco, CA, v. 86, n. 6, p. 966–971, 2012.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18460
dc.identifier10.4269/ajtmh.2012.12-0040
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868216
dc.descriptionTo assess the effect of the rapid removal of potentially infectious dogs on the prevalence and incidence of canine infections, a prospective study was undertaken in an area endemic for Leishmania infantum. We used serological testing based on the rapid DPP rK28 fusion protein chromatographic immunoassay for this dog screening-and-culling intervention trial. The outcome was evaluated by measuring seropositivity and sero-conversion/-reversion rates for canine infection. Our estimates indicated that concomitant detection and elimination of seropositive dogs with active disease may affect the numbers of canine infections and disease burden temporarily, although it is insufficient as a measure to interrupt the zoonotic L. infantum transmission. However, most of the asymptomatic, seropositive dogs continuously exhibit low levels of antibodies and/or reverted, remaining seronegative thereafter. In the process of waiting for an effective vaccine, one option for canine reservoir control may be to identify these possibly genetically resistant animals and promote their expansion in the population.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.subjectLeishmania
dc.subjectLeishmania infantum
dc.subjectCães
dc.subjectInfecção
dc.subjectLeishmania
dc.subjectLeishmania infantum
dc.subjectDogs
dc.subjectInfection
dc.subjectHigh Transmission Rates
dc.subjectLeishmania
dc.subjectCães
dc.subjectInfecção
dc.subjectLeishmania infantum
dc.titleThe effect of removing potentially infectious dogs on the numbers of Canine Leishmania infantum Infections in an endemic area with high transmission rates
dc.typeArticle


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