Co-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil

dc.creatorFabri, Allison Araújo
dc.creatorRodrigues, Cintia Damasceno dos Santos
dc.creatorSantos, Carolina Cardoso dos
dc.creatorChalhoub, Flávia Löwen Levy
dc.creatorSampaio, Simone Alves
dc.creatorFaria, Nieli Rodrigues da Costa
dc.creatorTorres, Maria Celeste
dc.creatorFonseca, Vagner
dc.creatorBrasil, Patricia
dc.creatorCalvet, Guilherme
dc.creatorAlcantara, Luiz Carlos Junior
dc.creatorFilippis, Ana Maria Bispo de
dc.creatorGiovanetti, Marta
dc.creatorBruycker-Nogueira, Fernanda de
dc.date2021-01-25T21:12:27Z
dc.date2021-01-25T21:12:27Z
dc.date2020
dc.date.accessioned2023-09-26T21:02:36Z
dc.date.available2023-09-26T21:02:36Z
dc.identifierFABRI, Allison Araújo et al. Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil. Pathogens, v. 9, n. 12, p. 1-12, 2020.
dc.identifier2076-0817
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/45814
dc.identifier10.3390/pathogens9120984
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868213
dc.descriptionThe Chikungunya virus infection in Brazil has raised several concerns due to the rapid dissemination of the virus and its association with several clinical complications. Nevertheless, there is limited information about the genomic epidemiology of CHIKV circulating in Brazil from surveillance studies. Thus, to better understand its dispersion dynamics in Rio de Janeiro (RJ), one of the most affected states during the 2016-2019 epidemic waves, we generated 23 near-complete genomes of CHIKV isolates from two main cities located in the metropolitan mesoregion, obtained directly from clinical samples. Our phylogenetic reconstructions suggest the 2019-CHIKV-ECSA epidemic in RJ state was characterized by the co-circulation of multiple clade (clade A and B), highlighting that two independent introduction events of CHIKV-ECSA into RJ state have occurred between 2016-2019, both mediated from the northeastern region. Interestingly, we identified that the two-clade displaying eighteen characteristic amino acids changes among structural and non-structural proteins. Our findings reinforce that genomic data can provide information about virus genetic diversity and transmission dynamics, which might assist in the arbovirus epidemics establishing of an effective surveillance framework.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectBrazil
dc.subjectECSA genotype
dc.subjectChikungunya virus
dc.subjectCo-circulation
dc.subjectPersistence
dc.subjectRio de Janeiro
dc.titleCo-circulation of two independent clades and persistence of chikv-ecsa genotype during epidemic waves in rio de janeiro, southeast brazil
dc.typeArticle


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