dc.creator | Francesconi, Glaucia | |
dc.creator | Valle, Antonio Carlos Francesconi do | |
dc.creator | Passos, Sonia Lambert | |
dc.creator | Barros, Mônica Bastos de Lima | |
dc.creator | Paes, Rodrigo de Almeida | |
dc.creator | Curi, André Luiz Land | |
dc.creator | Liporage, José | |
dc.creator | Porto, Cássio Ferreira | |
dc.creator | Gutierrez-Galhardo, Maria Clara | |
dc.date | 2019-05-30T12:59:49Z | |
dc.date | 2019-05-30T12:59:49Z | |
dc.date | 2011 | |
dc.date.accessioned | 2023-09-26T21:02:34Z | |
dc.date.available | 2023-09-26T21:02:34Z | |
dc.identifier | FRANCESCONI, Glaucia et al. Comparative study of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis. Mycopathologia, v. 171, p. 349-354, 2011. | |
dc.identifier | 0301-486X | |
dc.identifier | https://www.arca.fiocruz.br/handle/icict/33285 | |
dc.identifier | 10.1007/s11046-010-9380-8 | |
dc.identifier | 1573-0832 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8868205 | |
dc.description | Itraconazole is currently used for the treatment of cutaneous sporotrichosis. Terbinafine at a daily dose of 250 mg has been successfully applied to the treatment of cutaneous sporotrichosis. Objective: To compare the efficacy of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis. Materials and methods: A bidirectional cohort study was conducted on 55 patients receiving 250 mg/day terbinafine and 249 patients receiving 100 mg/day itraconazole. The latter patients were matched for age and clinical form to the terbinafine group at a ratio of 5:1. Sporothrix schenckii was isolated by culture
from all patients (age range: 18–70 years), who were submitted to the standard care protocol consisting of
clinical and laboratory evaluation and periodic visits. Results: Cure was observed in 51 (92.7%) patients of the terbinafine group and 229 (92%) of the itraconazole group within a similar mean period of time (11.5 and 11.8 weeks, respectively). An increase in the terbinafine dose to 500 mg was necessary in two patients due to the lack of a response, and one patient presented recurrence. In the itraconazole group, two patients required a dose increase and three presented recurrence. Adverse events were equally frequent among patients receiving terbinafine (n = 4, 7.3%) and itraconazole (n = 19, 7.6%) and were generally mild without the need for drug discontinuation, except for two patients of the itraconazole group. Conclusion: Terbinafine administered at a daily dose of 250 mg is an effective and well-tolerated option for the treatment of cutaneous sporotrichosis. | |
dc.description | 2020-05-30 | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | Springer Verlag | |
dc.rights | open access | |
dc.subject | Sporotrichosis | |
dc.subject | Itraconazole | |
dc.subject | Terbinafine | |
dc.subject | Treatment | |
dc.title | Comparative study of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis | |
dc.type | Article | |