dc.creatorSantos, Luciano Cincurá Silva
dc.creatorRamos, Eduardo Antônio Gonçalves
dc.creatorGurgel, Clarissa Araújo Silva
dc.creatorSantana, Edmar José Borges de
dc.creatorSantos, Jean Nunes dos
dc.date2015-05-05T17:36:10Z
dc.date2015-05-05T17:36:10Z
dc.date2007
dc.date.accessioned2023-09-26T21:01:52Z
dc.date.available2023-09-26T21:01:52Z
dc.identifierSANTOS, L. C. et al. Immunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts. Journal of Molecular Histology, v. 38, n. 3, p. 201-205, 2007.
dc.identifier1567-2379
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10243
dc.identifier10.1007/s10735-007-9088-3
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868013
dc.descriptionObjective Dental granulomas (DGs) and radicular cysts (RCs) are chronic periapical lesions frequently involving the jaws. Langerhans cells (LCs) are dendritic cells responsible for the presentation of antigens to T lymphocytes. This study examined the expression of LCs in DG and RCs by immunohistochemical staining. Study Design Eighteen cases of DGs and 26 cases of RCs were analyzed using anti-CD1a marker. Results CD1a-labeled LCs were observed in 11.1% of DGs and in 69.2% of RCs, showing a significant correlation (P < 0.0001; Fisher’s test). In DGs, LCs were only observed in granulation tissue, showing discrete immunostaining density. In RCs, LCs exhibited both a round and a dendritic shape in all epithelial layers. Although a correlation was observed between immunostaining density and epithelial thickness, as well as between immunostaining and inflammatory intensity, the differences were not significant in radicular cysts.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag
dc.rightsopen access
dc.subjectRadicular cyst
dc.subjectDental granuloma
dc.subjectImmunohistochemistry
dc.subjectLangerhans cell
dc.subjectCélulas de Langerhans/imunologia
dc.subjectGranuloma Periapical/imunologia
dc.subjectCisto Radicular/imunologia
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectIdoso
dc.subjectAntígenos CD1/imunologia
dc.subjectCriança
dc.subjectPré-Escolar
dc.subjectFemenino
dc.subjectHumanos
dc.subjectImuno-Histoquímica
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectGranuloma Periapical/patologia
dc.subjectCisto Radicular/patologia
dc.titleImmunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts.
dc.typeArticle


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