Immunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts.

dc.creatorSantos, Luciano Cincurá Silva
dc.creatorRamos, Eduardo Antônio Gonçalves
dc.creatorGurgel, Clarissa Araújo Silva
dc.creatorSantana, Edmar José Borges de
dc.creatorSantos, Jean Nunes dos
dc.date2015-05-05T17:36:10Z
dc.date2015-05-05T17:36:10Z
dc.date2007
dc.date.accessioned2023-09-26T21:01:52Z
dc.date.available2023-09-26T21:01:52Z
dc.identifierSANTOS, L. C. et al. Immunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts. Journal of Molecular Histology, v. 38, n. 3, p. 201-205, 2007.
dc.identifier1567-2379
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10243
dc.identifier10.1007/s10735-007-9088-3
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8868013
dc.descriptionObjective Dental granulomas (DGs) and radicular cysts (RCs) are chronic periapical lesions frequently involving the jaws. Langerhans cells (LCs) are dendritic cells responsible for the presentation of antigens to T lymphocytes. This study examined the expression of LCs in DG and RCs by immunohistochemical staining. Study Design Eighteen cases of DGs and 26 cases of RCs were analyzed using anti-CD1a marker. Results CD1a-labeled LCs were observed in 11.1% of DGs and in 69.2% of RCs, showing a significant correlation (P < 0.0001; Fisher’s test). In DGs, LCs were only observed in granulation tissue, showing discrete immunostaining density. In RCs, LCs exhibited both a round and a dendritic shape in all epithelial layers. Although a correlation was observed between immunostaining density and epithelial thickness, as well as between immunostaining and inflammatory intensity, the differences were not significant in radicular cysts.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag
dc.rightsopen access
dc.subjectRadicular cyst
dc.subjectDental granuloma
dc.subjectImmunohistochemistry
dc.subjectLangerhans cell
dc.subjectCélulas de Langerhans/imunologia
dc.subjectGranuloma Periapical/imunologia
dc.subjectCisto Radicular/imunologia
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectIdoso
dc.subjectAntígenos CD1/imunologia
dc.subjectCriança
dc.subjectPré-Escolar
dc.subjectFemenino
dc.subjectHumanos
dc.subjectImuno-Histoquímica
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectGranuloma Periapical/patologia
dc.subjectCisto Radicular/patologia
dc.titleImmunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts.
dc.typeArticle


Este ítem pertenece a la siguiente institución