Flavonoids from Siparuna cristata as Potential Inhibitors of SARS‑CoV‑2 Replication

dc.creatorLeal, Carla Monteiro
dc.creatorLeitão, Suzana Guimarães
dc.creatorSausset, Romain
dc.creatorMendonça, Simony C.
dc.creatorNascimento, Pedro H. A.
dc.creatorCheohen, Caio Felipe de Araujo R.
dc.creatorEsteves, Maria Eduarda A.
dc.creatorSilva, Manuela Leal da
dc.creatorGondim, Tayssa Santos
dc.creatorMonteiro, Maria Eduarda S.
dc.creatorTucci, Amanda Resende
dc.creatorFintelman‑Rodrigues, Natália
dc.creatorSiqueira, Marilda Agudo Mendonça Teixeira de
dc.creatorMiranda, Milene Dias
dc.creatorCosta, Fernanda N.
dc.creatorSimas, Rosineide C.
dc.creatorLeitão, Gilda Guimarães
dc.date2022-01-30T13:31:13Z
dc.date2022-01-30T13:31:13Z
dc.date2021
dc.date.accessioned2023-09-26T21:01:46Z
dc.date.available2023-09-26T21:01:46Z
dc.identifierLEAL, Carla Monteiro et al. Flavonoids from Siparuna cristata as Potential Inhibitors of SARS‑CoV‑2 Replication. Revista Brasileira de Farmacognosia, p . 1 - 9, July 2021.
dc.identifier1981-528X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/50948
dc.identifier10.1007/s43450-021-00162-5
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867984
dc.descriptionThe novel coronavirus SARS-CoV-2 has been affecting the world, causing severe pneumonia and acute respiratory syndrome, leading people to death. Therefore, the search for anti-SARS-CoV-2 compounds is pivotal for public health. Natural products may present sources of bioactive compounds; among them, flavonoids are known in literature for their antiviral activity. Siparuna species are used in Brazilian folk medicine for the treatment of colds and flu. This work describes the isolation of 3,3′,4′-tri-O-methyl-quercetin, 3,7,3′,4′-tetra-O-methyl-quercetin (retusin), and 3,7-di-O-methyl-kaempferol (kumatakenin) from the dichloromethane extract of leaves of Siparuna cristata (Poepp. & Endl.) A.DC., Siparunaceae, using high-speed countercurrent chromatography in addition to the investigation of their inhibitory effect against SARS-CoV-2 viral replication. Retusin and kumatakenin inhibited SARS-CoV-2 replication in Vero E6 and Calu-3 cells, with a selective index greater than lopinavir/ritonavir and chloroquine, used as control. Flavonoids and their derivatives may stand for target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsopen access
dc.subjectCromatografia de contracorrente
dc.subjectSiparunaceae
dc.subjectEspectrometria de massa
dc.subjectFlavonóides O-metil
dc.subjectCoronavírus
dc.subjectCountercurrent chromatography
dc.subjectSiparunaceae
dc.subjectMass spectrometry
dc.subjectO-Methyl flavonoids
dc.subjectCoronavirus
dc.titleFlavonoids from Siparuna cristata as Potential Inhibitors of SARS‑CoV‑2 Replication
dc.typeArticle


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