P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions.

dc.creatorQueiroz, Conceição
dc.creatorSilva, Tânia Maria Correia
dc.creatorAlves, Venâncio Avancini Ferreira
dc.creatorVilla, Luisa L.
dc.creatorCosta, Maria Cecília
dc.creatorTravassos, Ana Gabriela Álvares
dc.creatorAraújo Filho, José Bouzas
dc.creatorStudart, Eduardo
dc.creatorCheto, Tatiana
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.date2014-06-12T14:04:19Z
dc.date2014-06-12T14:04:19Z
dc.date2006
dc.date.accessioned2023-09-26T21:01:38Z
dc.date.available2023-09-26T21:01:38Z
dc.identifierQUEIROZ, C. et al. P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathology Research Practice, v. 202, n. 2, p. 77-83, 2006.
dc.identifier0344-0338
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7818
dc.identifier10.1016/j.prp.2005.08.012
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867952
dc.descriptionAn immunohistochemical analysis with monoclonal antibody p16INK4a was performed in formalin-fixed, paraffinembedded samples of 60 cases. The aim was to investigate in biopsies the expression of p16INK4a of normal uterine cervical tissue, pre-cancerous and cancerous lesions, and their relation with human papilloma virus (HPV) and HIV status. Three parameters were evaluated: percentage of p16INK4a positive cells, reaction intensity, and cell staining pattern. All of these parameters were statistically different when compared among different histological groups. However, logistic regression model showed that the reaction intensity was the best indicator of the expression of p16INK4a. This expression increases from normal to invasive squamous carcinoma. Sixty-six percent of the patients with CIN grade 1 (CIN1) expressed p16INK4a (all these cases were infected with high risk HPV). Our study supports the hypothesis that p16INK4a expression in pre-cancerous lesions and cancers can be used to identify HPV-transformed cells. Of great interest for routine diagnostic use is the fact that immunohistochemical testing for p16INK4a seems to be capable of identifying HPV-positive cells and potentially recognizing those lesions with an increased risk of progression to high-grade lesions
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectCervical neoplasia
dc.subjectDiagnostic marker
dc.subjectp16INK4a
dc.subjectHuman papillomavirus; Human immunodeficiency virus
dc.subjectNeoplasia Intraepitelial Cervical/diagnóstico
dc.subjectInibidor p16 de Quinase Ciclina-Dependente/metabolismo
dc.subjectLesões Pré-Cancerosas/diagnóstico
dc.subjectMarcadores Biológicos de Tumor/análise
dc.subjectNeoplasias do Colo do Útero/diagnóstico
dc.subjectCarcinoma/diagnóstico
dc.subjectNeoplasia Intraepitelial Cervical/complicações
dc.subjectFeminino
dc.subjectColo do Útero/metabolismo
dc.subjectInfecções por HIV/complicações
dc.subjectInfecções por HIV/diagnóstico
dc.subjectHumanos
dc.subjectImuno-Histoquímica
dc.subjectInfecções por Papillomavirus/complicações
dc.subjectInfecções por Papillomavirus/diagnóstico
dc.subjectPrognóstico
dc.titleP16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions.
dc.typeArticle


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