Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor

dc.creatorShoemaker, Charles B
dc.creatorRamachandran, Hema
dc.creatorLanda, Abraham
dc.creatorReis, Mitermayer Galvão dos
dc.creatorStein, Lincoln D
dc.date2014-05-06T11:53:58Z
dc.date2014-05-06T11:53:58Z
dc.date1992
dc.date.accessioned2023-09-26T21:01:25Z
dc.date.available2023-09-26T21:01:25Z
dc.identifierSHOEMAKER, C. et al. Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor. Molecular and Biochemical Parasitology, v. 53, n. 1-2, p. 17-32, 1992.
dc.identifier0166-6851
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7581
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867886
dc.descriptionThe complete coding DNA for a Schistosoma mansoni homologue of the epidermal growth factor receptor (SER) was characterized from cDNA clones obtained by homology to the tyrosine kinase domain of erbB. The DNA sequence predicts a 200-kDa translation product that contains a secretory leader, a cysteine-rich extracellular domain, a hydrophobic transmembrane sequence, and an intracellular tyrosine kinase domain. The SER transcript is present in cercariae and adult schistosomes. In addition to SER transcripts, schistosomes produce at least 3 variant transcripts encoding truncated SER products that include the secretory leader and a small portion of the extracellular domain followed by short sequences of unrelated, Cterminal amino acids. Based on these sequences, 2 of the variant mRNAs (class 2 and 5) appear to encode soluble, secreted proteins while one (class 4) encodes an SER variant protein with a hydrophobic C-terminus that may serve as a membrane anchor. Class 2 SER variant transcripts are present at levels comparable to SER transcripts in adult worms but are not detected in cercariae. Class 4 and 5 SER variant transcripts are also found within adult worms but at lower levels. Genomic cloning and characterization demonstrate that the variant SER transcripts arise through alternative splicing of the SER gene
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Science Publishers B.V
dc.rightsopen access
dc.subjectSchistosome
dc.subjectSchistosoma mansoni
dc.subjectEGF
dc.subjectEGF receptor
dc.subjectAlternative splicing
dc.subjectMembrane protein
dc.subjectProcessamento de RNA
dc.subjectReceptor do Fator de Crescimento Epidérmico/genética
dc.subjectSchistosoma mansoni/genética
dc.subjectSequência de Aminoácidos
dc.subjectAnimais
dc.subjectSequência de Bases
dc.subjectClonagem Molecular
dc.subjectDNA/genética
dc.subjectProteínas de Helminto/genética
dc.subjectDados de Sequência Molecular
dc.subjectRNA Mensageiro/genética
dc.subjectHomologia de Sequência do Ácido Nucleico
dc.subjectTranscrição Genética
dc.titleAlternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor
dc.typeArticle


Este ítem pertenece a la siguiente institución