Specific schistosomiasis treatment as a strategy for disease control

dc.creatorCoura, José Rodrigues
dc.creatorConceição, Maria José
dc.date2018-11-29T13:34:54Z
dc.date2018-11-29T13:34:54Z
dc.date2010
dc.date.accessioned2023-09-26T21:01:20Z
dc.date.available2023-09-26T21:01:20Z
dc.identifierCOURA, José Rodrigues; CONCEIÇÃO, Maria José. Specific schistosomiasis treatment as a strategy for disease control. Mem Inst Oswaldo Cruz, v.105, n.4, p.598-603, July 2010.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/30313
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867863
dc.descriptionThe great hope for schistosomiasis treatment began with the development of oxamniquine and praziquantel. These drugs can be administered orally in a single dose and have a high curative power with minor side effects. In this study, we carried out a field experiment involving a population of 3,782 people. The population was examined at four localities in Minas Gerais within the valleys of the Doce and Jequitinhonha Rivers. In this cohort, there were 1,790 patients infected with Schistosoma mansoni (47.3%) and we showed that only 1,403 (78.4%) could be treated with oxamniquine in a single dose of 12.5-20 mg/kg orally. The other 387 (21.6%) were not treated during the first stage because of contraindications (pregnancy or impeditive diseases), absences or refusals. It was observed that, on average, 8.8-17% of the infected patients continued to excrete S. mansoni eggs at the end of the 2nd month after treatment and 30-32% of the cohort was infected by the end of the 24th month. In one of the areas that we followed-up for a total of 30 years, the prevalence of the infection with S. mansoni fell from 60.8-19.3% and the hepatosplenic form of the disease dropped from 5.8-1.3%. We conclude that specific treatment of schistosomiasis reduces the prevalence of infection in the short-term and the morbidity due to schistosomiasis in medium to long-term time frames, but does not help to control disease transmission.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectEsquistossomose
dc.subjectTratamento específico
dc.subjectTransmissão
dc.subjectControle da morbidade
dc.subjectschistosomiasis
dc.subjectspecific treatment
dc.subjecttransmission
dc.subjectmorbidity control
dc.titleSpecific schistosomiasis treatment as a strategy for disease control
dc.typeArticle


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