The Primary Duct of Bothrops jararaca Glandular Apparatus Secretes Toxins

dc.creatorValente, Richard Hemmi
dc.creatorSakai, Fernanda
dc.creatorPortes Junior, José Antonio
dc.creatorViana, Luciana Godoy
dc.creatorCarneiro, Sylvia Mendes
dc.creatorPerales, Jonas
dc.creatorYamanouye, Norma
dc.date2018-09-27T15:47:59Z
dc.date2018-09-27T15:47:59Z
dc.date2018
dc.date.accessioned2023-09-26T21:01:04Z
dc.date.available2023-09-26T21:01:04Z
dc.identifierVALENTE, Richard Hemmi; et al. The Primary Duct of Bothrops jararaca Glandular Apparatus Secretes Toxins. Toxins, v.10, n.121, 13p, 2018.
dc.identifier2072-6651
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29110
dc.identifier10.3390/toxins10030121
dc.identifier2072-6651
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867793
dc.descriptionDespite numerous studies concerning morphology and venom production and secretion in the main venom gland (and some data on the accessory gland) of the venom glandular apparatus of Viperidae snakes, the primary duct has been overlooked. We characterized the primary duct of the Bothrops jararaca snake by morphological analysis, immunohistochemistry and proteomics. The duct has a pseudostratified epithelium with secretory columnar cells with vesicles of various electrondensities, as well as mitochondria-rich, dark, basal, and horizontal cells. Morphological analysis, at different periods after venom extraction, showed that the primary duct has a long cycle of synthesis and secretion, as do the main venom and accessory glands; however, the duct has a mixed mode venom storage, both in the lumen and in secretory vesicles. Mouse anti-B. jararaca venom serum strongly stained the primary duct's epithelium. Subsequent proteomic analysis revealed the synthesis of venom toxins-mainly C-type lectin/C-type lectin-like proteins. We propose that the primary duct's toxin synthesis products complement the final venom bolus. Finally, we hypothesize that the primary duct and the accessory gland (components of the venom glandular apparatus) are part of the evolutionary path from a salivary gland towards the main venom gland.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectBothrops jararaca
dc.subjectaparelho glandular de veneno
dc.subjectduto primário
dc.subjectmorfologia
dc.subjectciclo secretor
dc.subjectprodução de veneno
dc.subjectproteômica
dc.subjectvenom glandular apparatus
dc.subjectprimary duct
dc.subjectmorphology
dc.subjectsecretory cycle
dc.subjectvenom production
dc.subjectproteomics
dc.subjectBothrops jararaca
dc.titleThe Primary Duct of Bothrops jararaca Glandular Apparatus Secretes Toxins
dc.typeArticle


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