PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion

dc.creatorBaptista, Abrahão Fontes
dc.creatorGoes, Bruno Teixeira
dc.creatorMenezes, Diego Silva
dc.creatorGomes, Flavia Carvalho Alcantara
dc.creatorCavalcanti, João Zugaib
dc.creatorSilva, Joice Stipursky
dc.creatorGomes, Joyce R. S
dc.creatorOliveira, Julia Teixeira
dc.creatorSantos, Marcos André Vannier dos
dc.creatorMartinez, Ana Maria Blanco
dc.date2015-04-15T12:59:17Z
dc.date2015-04-15T12:59:17Z
dc.date2009
dc.date.accessioned2023-09-26T21:00:42Z
dc.date.available2023-09-26T21:00:42Z
dc.identifierBAPTISTA, A. F. et al. PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion. Journal of the Peripheral Nervous system, v. 14, n. 4, p. 285-293, 2009.
dc.identifier1085-9489
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10000
dc.identifier10.1111/j.1529-8027.2009.00240.x
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867686
dc.descriptionThe use of electromagnetic fields has been reported to enhance peripheralnerve regeneration. This study aimed to identify the effects of a prolonged protocolof low-frequency pulsed electromagnetic field (PEMF) on peripheral nerve regeneration.Thirty-four male Swiss mice (Mus musculus) were divided into PEMF (n= 17) and control(n= 17) groups. All animals underwent a unilateral sciatic-crush lesion, and the PEMF groupwas exposed to a 72-Hz, 2-G electromagnetic field for 30 min, five days a week, for threeweeks. Functional analysis was carried out weekly. After three weeks, the animals wereeuthanized, and histological, morphometric, oxidative stress, and TGF-β1 analyses wereperformed. Functional analysis showed no differences between the groups. Histologicalappearance was similar between PEMF and control nerves. Morphometric assessmentshowed that the PEMF nerves trended toward decreased regeneration. The levels of freeradicals were more pronounced in PEMF nerves, but were not associated with an increasein the content of the TGF-β1/Smad signaling pathway. Prolonged PEMF regimen leads todelayed histological peripheral nerve regeneration and increased oxidative stress but noloss of function recovery
dc.formatapplication/pdf
dc.languageeng
dc.publisherWoodland Publications
dc.rightsopen access
dc.subjectElectromagnetic fields
dc.subjectMouse
dc.subjectRegeneration
dc.subjectSciatic nerve lesion
dc.subjectTerapia de Campo Magnético
dc.subjectRegeneração Nervosa
dc.subjectNervo Isquiático
dc.subjectNeuropatia Ciática
dc.subjectCamundongos
dc.titlePEMF fails to enhance nerve regeneration after sciatic nerve crush lesion
dc.typeArticle


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