Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization

dc.creatorAliberti, Julio
dc.creatorViola, João P. B.
dc.creatorAbreu, Adriana Vieira de
dc.creatorBozza, Patrícia T.
dc.creatorSher, Alan
dc.creatorScharfstein, Julio
dc.date2020-04-21T15:57:57Z
dc.date2020-04-21T15:57:57Z
dc.date2003
dc.date.accessioned2023-09-26T21:00:29Z
dc.date.available2023-09-26T21:00:29Z
dc.identifierALIBERTI, Julio et al. Cutting Edge: Bradykinin Induces IL-12 Production by Dendritic Cells: A Danger Signal That Drives Th1 Polarization. Journal of Immunology, v. 170, p. 5349-5353, 2003.
dc.identifier0022-1767
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40906
dc.identifier10.4049/jimmunol.170.11.5349
dc.identifier1550-6606
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867628
dc.descriptionAcesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/170/11/5349.full.pdf
dc.descriptionDendritic cells play a major role in the induction of both innate and acquired immune responses against pathogenic invaders. These cells are also able to sense endogenous activation signals liberated by injured tissues even in the absence of infection. In the present work, we demonstrate that kinins mobilize dendritic cells to produce IL-12 through activation of the B(2) bradykinin receptor subtype and that bradykinin-induced IL-12 responses are tightly regulated both by angiotensin-converting enzyme, a kinin-degrading peptidase, and by endogenous IL-10. Using a mouse model of allergic inflammation, we further show that addition of bradykinin to OVA during immunization results in decreased eosinophil infiltration on Ag challenge. The latter effect was demonstrated to be due to IL-12-driven skewing of Ag-specific T cell responses to a type 1 cytokine profile. Our data thus indicate that kinin peptides can serve as danger signals that trigger dendritic cells to produce IL-12 through activation of B(2) bradykinin receptors.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Association of Immunologists
dc.rightsopen access
dc.subjectBradykinin
dc.subjectProdução de IL-12
dc.subjectCélulas Dendríticas
dc.subjectTh1 Polarização
dc.subjectBradykinin
dc.subjectDendritic Cells
dc.subjectTh1 Polarization
dc.subjectIL-12 Production
dc.titleCutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization
dc.typeArticle


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