Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling

dc.creatorBarisón, María Julia
dc.creatorNogoceke, Rodrigo
dc.creatorJosino, Raphaella
dc.creatorHorinouchi, Cintia Delai da Silva
dc.creatorMarcon, Bruna Hilzendeger
dc.creatorCorrea, Alejandro
dc.creatorStimamiglio, Marco Augusto
dc.creatorRobert, Anny Waloski
dc.date2022-08-16T17:31:31Z
dc.date2022-08-16T17:31:31Z
dc.date2022
dc.date.accessioned2023-09-26T21:00:18Z
dc.date.available2023-09-26T21:00:18Z
dc.identifierBARISÓN, María Julia et al. Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling. Int. J. Mol. Sci, v. 23, n. 6010, p. 1–22, 2022.
dc.identifier1422-0067
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/54664
dc.identifier10. https:// doi.org/10.3390/ijms23116010
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867577
dc.descriptionCartilage repair has been a challenge in the medical field for many years. Although treatments that alleviate pain and injury are available, none can effectively regenerate the cartilage. Currently, regenerative medicine and tissue engineering are among the developed strategies to treat cartilage injury. The use of stem cells, associated or not with scaffolds, has shown potential in cartilage regeneration. However, it is currently known that the effect of stem cells occurs mainly through the secretion of paracrine factors that act on local cells. In this review, we will address the use of the secretome—a set of bioactive factors (soluble factors and extracellular vesicles) secreted by the cells—of mesenchymal stem cells as a treatment for cartilage regeneration. We will also discuss methodologies for priming the secretome to enhance the chondroregenerative potential. In addition, considering the difficulty of delivering therapies to the injured cartilage site, we will address works that use hydrogels functionalized with growth factors and secretome components. We aim to show that secretome-functionalized hydrogels can be an exciting approach to cell-free cartilage repair therapy.
dc.formatapplication/pdf
dc.languagepor
dc.publisherMDPI
dc.rightsopen access
dc.subjectCartilage
dc.subjectSecretome
dc.subjectHydrogels
dc.subjectConnective Tissue Growth Factor
dc.subjectExtracellular Vesicles
dc.subjectCartílago
dc.subjectHidrogeles
dc.subjectFactor de Crecimiento del Tejido Conjuntivo
dc.subjectVesículas Extracelulares
dc.subjectCartilagem
dc.subjectSecretoma
dc.subjectHidrogéis
dc.subjectFator de Crescimento do Tecido Conjuntivo
dc.subjectVesículas Extracelulares
dc.titleFunctionalized hydrogels for cartilage repair: the value of secretome-instructive signaling
dc.typeArticle


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