Microglial Priming in Infections and Its Risk to Neurodegenerative Diseases

dc.creatorLima, Maiara N.
dc.creatorSilva, Maria C. Barbosa
dc.creatorMaron-Gutierrez, Tatiana
dc.date2022-08-17T11:09:33Z
dc.date2022-08-17T11:09:33Z
dc.date2022
dc.date.accessioned2023-09-26T21:00:10Z
dc.date.available2023-09-26T21:00:10Z
dc.identifierLIMA, Maiara N.; SILVA, Maria C. Barbosa; MARON-GUTIERREZ, Tatiana. Microglial Priming in Infections and Its Risk to Neurodegenerative Diseases. Frontiers in Cellular Neuroscience. v. 16, Article 878987, p. 1 - 13, June 2022.
dc.identifier1662-5102
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/54674
dc.identifier10.3389/fncel.2022.878987
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867541
dc.descriptionInfectious diseases of different etiologies have been associated with acute and long-term neurological consequences. The primary cause of these consequences appears to be an inflammatory process characterized primarily by a pro-inflammatory microglial state. Microglial cells, the local effectors’ cells of innate immunity, once faced by a stimulus, alter their morphology, and become a primary source of inflammatory cytokines that increase the inflammatory process of the brain. This inflammatory scenario exerts a critical role in the pathogenesis of neurodegenerative diseases. In recent years, several studies have shown the involvement of the microglial inflammatory response caused by infections in the development of neurodegenerative diseases. This has been associated with a transitory microglial state subsequent to an inflammatory response, known as microglial priming, in which these cells are more responsive to stimuli. Thus, systemic inflammation and infections induce a transitory state in microglia that may lead to changes in their state and function, making priming them for subsequent immune challenges. However, considering that microglia are long-lived cells and are repeatedly exposed to infections during a lifetime, microglial priming may not be beneficial. In this review, we discuss the relationship between infections and neurodegenerative diseases and how this may rely on microglial priming.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectMicroglia pró-inflamatória
dc.subjectPrimário microglial
dc.subjectDoenças infecciosas
dc.subjectDoenças neurodegenerativas
dc.subjectEnvelhecimento
dc.subjectInflamação do sistema nervoso central
dc.subjectInflamação cerebral
dc.subjectPro-inflammatory microglia
dc.subjectMicroglial priming
dc.subjectInfectious diseases
dc.subjectNeurodegenerative diseases
dc.subjectAging
dc.subjectCentral nervous system inflammation
dc.subjectBrain inflammation
dc.titleMicroglial Priming in Infections and Its Risk to Neurodegenerative Diseases
dc.typeArticle


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