Influence of the Notch system in the therapeutic response of American tegumentary leishmaniasis

dc.creatorRodrigues, K. M .P.
dc.creatorOliveira, M. P.
dc.creatorMaretti-Mira, A. C.
dc.creatorOliveira.Neto, M. P.
dc.creatorMattos, M. S.
dc.creatorSilva, L.
dc.creatorSoares, D. A.
dc.creatorDolci, E. L. L.
dc.creatorPerico, R. A. P. N.
dc.creatorPirmez, C.
dc.date2018-04-19T12:35:45Z
dc.date2018-04-19T12:35:45Z
dc.date2011
dc.date.accessioned2023-09-26T21:00:09Z
dc.date.available2023-09-26T21:00:09Z
dc.identifierRODRIGUES, K. M. P. et al. Influence of the Notch system in the therapeutic response of American tegumentary leishmaniasis. British Journal of Dermatology, v. 164, p. 1228-1234, 2011.
dc.identifier0007-0963
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25940
dc.identifier10.1111/j.1365-2133.2011.10240.x
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867537
dc.descriptionThe evolution and therapeutic outcome of American tegumentary leishmaniasis (ATL) depend upon many factors, including the balance between Th1 and Th2 cytokines to control parasite multiplication and lesion extension. Other cytokines known for their role in inflammatory processes such as interleukin IL-17 or IL-18 as well as factors controlling keratinocyte differentiation and the inflammatory process in the skin, like the Notch system, could also be involved in the disease outcome. Notch receptors are a group of transmembrane proteins that regulate cell fate decisions during development and adulthood in many tissues, including keratinocyte differentiation and T-cell lineage commitment, depending on their activation by specific groups of ligands (Delta-like or Jagged).
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectLeishmaniose tegumentar americana
dc.subjectResposta terapêutica
dc.subjectNotch system
dc.subjectTherapeutic
dc.subjectTherapeutic response
dc.titleInfluence of the Notch system in the therapeutic response of American tegumentary leishmaniasis
dc.typeArticle


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