Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum

dc.creatorPrestes, Elisa Beatriz
dc.creatorBayer-Santos, Ethel
dc.creatorStoco, Patrícia Hermes
dc.creatorSincero, Thaís Cristine Marques
dc.creatorWagner, Glauber
dc.creatorUmaki, Adriana
dc.creatorFragoso, Stenio Perdigão
dc.creatorBordignon, Juliano
dc.creatorSteindel, Mário
dc.creatorGrisard, Edmundo Carlos
dc.date2019-12-20T17:52:45Z
dc.date2019-12-20T17:52:45Z
dc.date2012
dc.date.accessioned2023-09-26T20:59:55Z
dc.date.available2023-09-26T20:59:55Z
dc.identifierPRESTES, Elisa Beatriz et al. Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite’s flagellum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 6, p. 713-719, 2012.
dc.identifier1678-8060
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/38779
dc.identifier10.1590/s0074-02762012000600002
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867480
dc.descriptionProtein tyrosine phosphatases (PTPs) play an essential role in the regulation of cell differentiation in pathogenic trypanosomatids. In this study, we describe a PTP expressed by the non-pathogenic protozoan Trypanosoma rangeli (TrPTP2). The gene for this PTP is orthologous to the T. brucei TbPTP1 and Trypanosoma cruzi (TcPTP2) genes. Cloning and expression of the TrPTP2 and TcPTP2 proteins allowed anti-PTP2 monoclonal antibodies to be generated in BALB/c mice. When expressed by T. rangeli epimastigotes and trypomastigotes, native TrPTP2 is detected as a ~65 kDa protein associated with the parasite's flagellum. Given that the flagellum is an important structure for cell differentiation in trypanosomatids, the presence of a protein responsible for tyrosine dephosphorylation in the T. rangeli flagellum could represent an interesting mechanism of regulation in this structure.
dc.formatapplication/pdf
dc.languagepor
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectTrypanosoma rangeli
dc.subjectProtein Tyrosine Phosphatases
dc.subjectFlagella
dc.subjectProteínas Tirosina Fosfatasas
dc.subjectProteínas Tirosina Fosfatases
dc.subjectFlagelos
dc.titleTrypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
dc.typeArticle


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