Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity

dc.creatorGomes, Regis Bernardo Brandim
dc.creatorBrodskyn, Claudia Ida
dc.creatorOliveira, Camila Indiani de
dc.creatorCosta, Jackson Mauricio Lopes
dc.creatorMiranda, José Carlos
dc.creatorCaldas, Arlene de Jesus Mendes
dc.creatorValenzuela, Jesus G
dc.creatorBarral Netto, Manoel
dc.creatorBarral, Aldina Maria Prado
dc.date2012-07-18T20:56:40Z
dc.date2012-07-18T20:56:40Z
dc.date2002
dc.date.accessioned2023-09-26T20:59:24Z
dc.date.available2023-09-26T20:59:24Z
dc.identifierGOMES, R.B. et al. Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity. Journal of Infectious Disease, v. 186, n. 10, p. 1530-4, nov. 2002.
dc.identifier0022-1899
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/4198
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867354
dc.descriptionAntibody responses to salivary gland sonicate (SGS) from Lutzomyia longipalpis were investigated using serum samples from individuals living in an area where visceral leishmaniasis is endemic. Individuals were classified into 2 groups, according to the alteration of their responses to Leishmania chagasi antigen over the course of 6 months. Group 1 included children who experienced anti-L. chagasi seroconversion from negative to positive; group 2 included children who experienced delayed-type hypersensitivity (DTH) response to L. chagasi antigen conversion from negative to positive. Individuals who experienced seroconversion against L. chagasi antigens did not have increased anti-saliva antibody response, whereas those who developed a positive anti-L. chagasi DTH response had increased immunoglobulin (Ig) G, IgG1 and IgE anti-SGS antibody levels. Despite wide variation, serum samples from individuals in group 2 recognized more bands in SGS than did those from individuals in group 1. This simultaneous appearance of anti-saliva humoral response and anti-L. chagasi cell-mediated immunity supports the hypothesis that induction of immune response against SGS can facilitate induction of a protective response against leishmaniasis
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectDoenças Endêmicas
dc.subjectHipersensibilidade Tardia/imunologia
dc.subjectImunoglobulina G/imunologia
dc.subjectLeishmania/imunologia
dc.subjectLeishmaniose/imunologia
dc.subjectPsychodidae/imunologia
dc.subjectFormação de Anticorpos/imunologia
dc.subjectCriança
dc.subjectHumanos
dc.subjectImunidade Celular/imunologia
dc.subjectLeishmaniose/epidemiologia
dc.subjectGlândulas Salivares/imunologia
dc.titleSeroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity
dc.typeArticle


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