Effects of maternal geohelminth infections on allergy in early childhood

dc.creatorCooper, Philip J
dc.creatorChico, Martha E
dc.creatorAmorim, Leila Denise Alves Ferreira
dc.creatorSandoval, Carlos
dc.creatorVaca, Maritza
dc.creatorStrina, Agostino
dc.creatorCampos, Ana Clara Paixão
dc.creatorRodrigues, Laura Cunha
dc.creatorBarreto, Maurício Lima
dc.creatorStrachan, David P
dc.date2017-08-01T13:40:06Z
dc.date2017-08-01T13:40:06Z
dc.date2016
dc.date.accessioned2023-09-26T20:59:00Z
dc.date.available2023-09-26T20:59:00Z
dc.identifierCOOPER, P. J. et al. Effects of maternal geohelminth infections on allergy in early childhood. Journal of Allergy and Clinical Immunology, v. 137, p. 899-906, 2016.
dc.identifier0091-6749
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20478
dc.identifier10.1016/j.jaci.2015.07.044
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867236
dc.descriptionBarreto, Mauricio Lima “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.descriptionWellcome Trust grant 088862/Z/09/Z.
dc.descriptionMaternal geohelminth infections during pregnancy may protect against allergy development in childhood. Objective: We sought to investigate the effect of maternal geohelminths on the development of eczema, wheeze, and atopy during the first 3 years of life. Methods: A cohort of 2404 neonates was followed to 3 years of age in a rural district in coastal Ecuador. Data on wheeze and eczema were collected by means of questionnaire and physical examination at 13, 24, and 36 months of age. Atopy was measured based on skin prick test (SPT) reactivity to 9 allergens at 36 months. Maternal stool samples were examined for geohelminths by microscopy. Data on potential confounders was collected after birth by questionnaire. Results: Geohelminths were observed in 45.9% of mothers. Eczema and wheeze were reported for 17.7% and 25.9%, respectively, of 2069 (86.1%) children with complete follow-up to 3 years, and allergen SPT reactivity to any allergen was present in 17.2% and to house dust mite in 8.7%. Maternal geohelminth infections were not significantly associated with eczema (adjusted odds ratio [OR], 1.26; 95% CI, 0.98-1.61), wheeze (adjusted OR, 1.02; 95% CI, 0.82-1.27), and SPT reactivity to any allergen (adjusted OR, 0.79; 95% CI, 0.61- 1.01). In subgroup analyses maternal geohelminths were associated with a significantly reduced risk of SPT reactivity to mite and other perennial allergens, and maternal ascariasis was associated with an increased risk of eczema and reduced risk of SPT reactivity to all allergens. Conclusion: Our data do not support a protective effect of maternal infections with geohelminth parasites during pregnancy against the development of eczema and wheeze in early childhood, although there was evidence in subgroup analyses for a reduction in SPT reactivity to house dust mites and perennial allergens.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Academy of Allergy, Asthma and Immunology
dc.rightsopen access
dc.subjectGeohelmintos
dc.subjectInfecções maternas
dc.subjectAtopia
dc.subjectSibilância
dc.subjectEczema
dc.subjectInfância
dc.subjectGeohelminths
dc.subjectMaternal infections
dc.subjectAtopy
dc.subjectWheeze
dc.subjectEczema
dc.subjectEarly childhood
dc.titleEffects of maternal geohelminth infections on allergy in early childhood
dc.typeArticle


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