Analysis of the genetic ancestry of patients with oral clefts from South American admixed populations

dc.creatorMachado, Camilla D. Vieira
dc.creatorCarvalho, Flavia M. de
dc.creatorSilva, Luiz C. Santana da
dc.creatorSantos, Sidney E. dos
dc.creatorMartins, Claudia
dc.creatorPoletta, Fernando A.
dc.creatorMereb, Juan C.
dc.creatorVieira, Alexandre R.
dc.creatorCastilla, Eduardo E.
dc.creatorOrioli, Iêda M.
dc.date2017-02-15T16:38:39Z
dc.date2017-02-15T16:38:39Z
dc.date2016
dc.date.accessioned2023-09-26T20:58:58Z
dc.date.available2023-09-26T20:58:58Z
dc.identifierMACHADO, Camilla D. Vieira; et al. Analysis of the genetic ancestry of patients with oral clefts from South American admixed populations. European Journal of Oral Sciences, v.124, n.4, p.406-411, Aug. 2016.
dc.identifier0909-8836
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/17827
dc.identifier10.1111/eos.12275
dc.identifier1600-0722
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867226
dc.descriptionIncreased susceptibility to cleft lip, with or without cleft palate (CL±P) has been observed in South America, as related to Amerindian ancestry, using epidemiological data, uniparental markers, and blood groups. In this study, it was evaluated whether this increased risk remains when Amerindian ancestry is estimated using autosomal markers and considered in the predictive model. Ancestry was estimated through genotyping 62 insertion and deletion (INDEL) markers in sample sets of patients with CL±P, patients with cleft palate (CP), and controls, from Patagonia in southern Argentina and Belém in northern Brazil. The Amerindian ancestry in patients from Patagonia with CL±P was greater than in controls although it did not reach statistical significance. The European ancestry in patients with CL±P from Belém and in patients with CP from Belém and Patagonia was higher than in controls and statistically significant for patients with CP who were from Belém. This high contribution of European genetic ancestry among patients with CP who were from Belém has not been previously observed in American populations. Our results do not corroborate the currently accepted risks for CL±P and CP estimated by epidemiological studies in the North American populations and probably reflect the higher admixture found in South American ethnic groups when compared with the same ethnic groups from the North American populations.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectFenda labial
dc.subjectFenda palatina
dc.subjectAscendência genética
dc.subjectPopulações sul-americanas
dc.subjectMutação INDEL
dc.subjectcleft lip and palate
dc.subjectcleft palate
dc.subjectgenetic ancestry
dc.subjectINDEL
dc.subjectSouth American populations
dc.titleAnalysis of the genetic ancestry of patients with oral clefts from South American admixed populations
dc.typeArticle


Este ítem pertenece a la siguiente institución