Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil

dc.creatorQueiroz, Artur Trancoso Lopo de
dc.creatorSantos, Luciane Amorim
dc.creatorMoreau, Domingos Ramon
dc.creatorOliveira, Tulio de
dc.creatorWatkins, David I
dc.creatorCastro Filho, Bernardo Galvão
dc.creatorAlcantara, Luiz Carlos Júnior
dc.date2011-08-08T19:15:22Z
dc.date2011-08-08T19:15:22Z
dc.date2007
dc.date.accessioned2023-09-26T20:58:52Z
dc.date.available2023-09-26T20:58:52Z
dc.identifierQUEIROZ, A. T. L. de. et al. Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil. The Brazilian Journal of Infectious Diseases, v.11, n.1, p.27-30, 2007.
dc.identifier1413-8670
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/2790
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867199
dc.descriptionAgradecimentos a ATLQ e LAS que contribuíram igualmente para este trabalho, além de Elisabeth Deliège por sua assistência técnica.
dc.descriptionPesquisa parcialmente financiada pela Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) e PN-DST/AIDS, Ministério da Saúde, Brasil.
dc.descriptionGenetic analysis of HIV-1 is essential to improve treatment strategies and select epitopes for vaccine programs. The objective of this study was to determine whether known CD4+ and CD8+ epitopes were present in Brazilian HIV-1 strains. We used previously described CD8+ and CD4+ epitopes from the Los Alamos laboratory to search for these epitopes in the Brazilian sequences using the HIVbase program and we compared the frequency results with the analyses using physical-chemical profile tools from Network Protein Sequence Analysis (NPSA), and the SYFPEITHI program. Furthermore, this analysis was carried out with the Prosite tool using the GeneDoc program and ds/dn analyses using the Synonymous Nonsynonymous Analysis Program (SNAP). The HIVbase epitope mapping demonstrated that 30 CD8+ and 6 CD4+ epitopes were present in the Brazilian sequences at a high frequency. Only two of these epitopes were heavily glycosylated. Interestingly, ds/dn analyses showed evidence of purifying selective pressure. These types of analyses could be useful for the assessment of possible vaccine efficiency in populations.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBrazilian Society of Infectious Diseases
dc.rightsopen access
dc.subjectHIV-1
dc.subjectVacina
dc.subjectEpitopo
dc.subjectGenes env
dc.subjectHIV-1
dc.subjectVaccine
dc.subjectEpitope
dc.subjectenv
dc.subjectBrasil
dc.subjectLinfócitos T CD4-Positivos
dc.subjectLinfócitos T CD8-Positivos
dc.subjectEpitopos
dc.subjectProdutos do Gene env
dc.subjectInfecções por HIV
dc.subjectHIV-1
dc.subjectHumanos
dc.titleIdentification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil
dc.typeArticle


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