Refractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia

dc.creatorTotino, Paulo Renato Rivas
dc.creatorDaniel-Ribeiro, Cláudio Tadeu
dc.creatorCruz, Maria de Fátima Ferreira da
dc.date2016-07-21T15:03:55Z
dc.date2016-07-21T15:03:55Z
dc.date2011
dc.date.accessioned2023-09-26T20:58:33Z
dc.date.available2023-09-26T20:58:33Z
dc.identifierTOTINO, Paulo Renato Rivas; DANIEL-RIBEIRO, Cláudio Tadeu; CRUZ, Maria de Fátima Ferreira da. Refractoriness of eryptotic red blood Cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia. Plos One, v. 6, n.10, p. 1-5, Oct. 2011.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/15040
dc.identifier10.1371/journal.pone.0026575
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867111
dc.descriptionRecently, we have described that apoptosis-like process of red blood cells (RBC) - eryptosis - in malaria is not restricted to parasitized cells, occurring also in non-parasitized RBC (nRBC). Besides to pathogenic proprieties, apoptosis also participates in the innate defense trough restriction of intracellular pathogens propagation. In the present study, we investigated the capacity of P. falciparum parasites to infect eryptotic RBC. Schizont parasitized RBC concentrated by magnetic separation were cultured with eryptotic RBC obtained by ionomycin treatment and, then, parasite growth was evaluated in Giemsa-stained thin blood smears. While parasites infected and developed normally in control non-eryptotic RBC, cultures performed with eryptotic RBC had a marked decrease in parasitaemia. It was noteworthy a great number of free merozoites in eryptotic RBC cultures, indicating that these cells were not susceptible to invasion. We suggest that although eryptosis could be involved in malaria pathogenesis, it could also acting protectively by controlling parasite propagation.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectPlasmodium falciparum
dc.subjectEritrócitos
dc.subjectMalária
dc.subjectPatogênese da malária
dc.subjectPlasmodium falciparum
dc.subjectParasitaemia
dc.subjectRed Blood Cells
dc.subjectMalaria
dc.subjectMalaria pathogenesis
dc.subjectMalária
dc.subjectEritrócitos
dc.subjectPlasmodium falciparum
dc.titleRefractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia
dc.typeArticle


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