Development of an experimental model of schistosomal myeloradiculopathy

dc.creatorCarvalho, Tiago Pinheiro Vaz de
dc.creatorFerrari, Teresa Cristina Abreu
dc.creatorSantana, Josimari Melo de
dc.creatorViana, Victor Antônio Santos
dc.creatorSantos, José Aislan Correia
dc.creatorNascimento, Wheverton Correia do
dc.creatorCruz, Kamilla Mayara Lucas da
dc.creatorAraújo, Karina Conceição Gomes Machado de
dc.date2017-05-12T19:43:11Z
dc.date2017-05-12T19:43:11Z
dc.date2017
dc.date.accessioned2023-09-26T20:58:09Z
dc.date.available2023-09-26T20:58:09Z
dc.identifierCARVALHO, Tiago Pinheiro Vaz de et al. Development of an experimental model of schistosomal myeloradiculopathy. Acta Trop., v. 167, p. 142-147, 2017.
dc.identifier1873-6254
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18839
dc.identifier10.1016/j.actatropica.2016.12.028
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867004
dc.descriptionSchistosomal myeloradiculopathy (SMR) is a severe form of presentation of schistosomiasis in which Schistosoma spp. affect the spinal cord. The aims of the present study were to develop an animal model of SMR caused by S. mansoni, to characterize both sensory and motor abnormalities in the infected animals, and to investigate the relationship of the sensory, motor and histological findings with the progression of the infection over time. Mechanical sensitivity and behavioral tests were performed followed by euthanasia in male Wistar rats divided into six groups of five animals each, on days 5, 10, 20 and 30 after infection of S. mansoni eggs. The controls were subjected to the same procedure but were administered phosphate-buffered saline (PBS). The spinal cord was removed and subjected to histological analysis. S. mansoni eggs were found in the spinal cord of 25% of the infected animals, which belonged to the groups that exhibited more significant reduction of the superficial mechanical sensitivity, thermal sensitivity and muscle strength. This model proved to be satisfactory to assess functional changes in Wistar rats and might be used in studies investigating the pathogenesis of SMR. To our knowledge, this is the first experimental model of SMR.
dc.formatapplication/pdf
dc.languagepor
dc.rightsrestricted access
dc.subjectModelos animais
dc.subjectNeuroesquistossomose
dc.subjectTeste de nocicepção
dc.subjectSchistosoma mansoni
dc.subjectDoença da medula espinhal
dc.subjectNeuroschistosomiasis
dc.subjectSchistosoma mansoni
dc.subjectAnimal models
dc.subjectSpinal cord disease
dc.subjectNociception test
dc.subjectModelos de Doença Animal
dc.subjectProgressão da doença
dc.subjectForça Muscular / fisiologia
dc.subjectNeuroesquistossomose / fisiopatologia
dc.subjectLimiares sensoriais / fisiologia
dc.subjectMedula espinhal / parasitologia
dc.titleDevelopment of an experimental model of schistosomal myeloradiculopathy
dc.typeArticle


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