Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition

dc.creatorLima, Flávia Oliveira de
dc.creatorAlves, Vivian
dc.creatorBarbosa Filho, José Maria
dc.creatorAlmeida, Jackson Roberto Guedes da Silva
dc.creatorRodrigues, Luis Cezar
dc.creatorSoares, Milena Botelho Pereira
dc.creatorVillarreal, Cristiane Flora
dc.date2013-10-25T18:58:31Z
dc.date2013-10-25T18:58:31Z
dc.date2012
dc.date.accessioned2023-09-26T20:58:09Z
dc.date.available2023-09-26T20:58:09Z
dc.identifierLIMA,F. O. et al. Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition. Phytotherapy Research, v. 27, p. 1557–1563, 2013.
dc.identifier10.1002/ptr.4902
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7210
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867001
dc.descriptionThe present study investigates the antinociceptive properties of lupeol inmodels of inflammatory and post-operative pain, as well as its mechanisms of action. The effects of lupeol were tested against acetic acid-induced writhing, formalin test, carrageenan-induced hyperalgesia, and post-operative pain model. Cytokine levels were determined by ELISA. Mice motor performance was evaluated in the rota rod and open-field tests. Pre-treatment of mice with lupeol (5–100mg/kg IP) produced a dose-related inhibition of writhing in mice. The maximal antinociception produced by lupeol (60mg/kg) was unaffected in mice pre-treated with yohimbine (a2 adrenoceptor antagonist; 2mg/kg IP), L-arginine (substrate for nitric oxide synthase; 600mg/kg IP), glibenclamide (the KATP-channel blocker; 2mg/kg IP), and methysergide maleate (serotoninergic receptors antagonist; 5mg/kg IP). Furthermore, lupeol (25–100mg/kg) inhibited the late phase of formalin test. Pre-treatment with lupeol (50 and 100mg/kg) inhibited the hyperalgesia and the local increase in tumor necrosis factor-a (TNF-a) and interleukin-1b (IL-1b) levels induced by carrageenan. In contrast, lupeol did not inhibit the post-operative pain. Lupeol-treated mice did not show any motor performance alterations or apparent systemic toxicity. Our results demonstrate that lupeol has consistent antinociceptive properties during inflammatory pain, but not post-operative pain, acting through the inhibition of IL-1b and TNF-a production.
dc.formatapplication/pdf
dc.languageeng
dc.publisherJohn Wiley & Sons, Ltd
dc.rightsopen access
dc.subjectLonchocarpus araripensis
dc.subjectLupeol
dc.subjectAntinociception
dc.subjectInflammatory pain
dc.subjectPost-operative pain
dc.subjectCytokines
dc.titleAntinociceptive effect of lupeol: evidence for a role of cytokines inhibition
dc.typeArticle


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