T Cell Activation and Cytokine Profile of Tuberculosis and HIV-Positive Individuals during Antituberculous Treatment and Efavirenz-Based Regimens

dc.creatorSilva, Tatiana P. da
dc.creatorGiacoia-Gripp, Carmem B. W.
dc.creatorSchmaltz, Carolina A.
dc.creatorSant`Anna, Flavia M.
dc.creatorRolla, Valeria
dc.creatorMorgado, Mariza G.
dc.date2015-08-19T13:49:17Z
dc.date2015-08-19T13:49:17Z
dc.date2013
dc.date.accessioned2023-09-26T20:58:02Z
dc.date.available2023-09-26T20:58:02Z
dc.identifierSILVA, Tatiana P. da; et al. T Cell Activation and Cytokine Profile of Tuberculosis and HIV-Positive Individuals during Antituberculous Treatment and Efavirenz-Based Regimens. Plos One, v.8, n.6, 8p, 2013.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/11473
dc.identifier10.1371/journal.pone.0066095
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8866973
dc.descriptionIntroduction: The profile of immune activation markers in tuberculosis and HIV-infected patients is already known. The impact of simultaneous infections on the immune parameters is still not fully explored. Methods: We conducted a prospective study to estimate trajectories of activated T cell subsets and the profile of anti- and pro-inflammatory cytokines in a group of HIV-TB individuals, previously naı¨ve for HAART, recruited from a randomized clinical trial during TB treatment and first antiretroviral therapy with efavirenz. Patients were evaluated according to the immunosuppression levels at baseline as group 1 (CD4,200 cells/mm3) and group 2 (CD4.200 cells/mm3). These parameters were measured at the time of HAART initiation (started about 30 days after the onset of TB treatment) and at the follow-up visits after 30, 60, 90 and 180 days. Trajectories were estimated using least squares estimates of the coefficients of a restricted cubic spline function in time after adjusting for subject effects, bootstrapping it 500 times. Results: Increase of CD4 T cell counts and suppression of HIV viral load were observed for all patients under HAART and TB treatment. Descendent trajectories were observed for the activated CD8+/CD38+ and CD3+/HLA-DR+ T cell subsets, and for plasma concentration of gamma- interferon (IFN-c). Except for TNF-a and IL-2 discrete variations were observed for the other cytokines. Differences in the trajectories of these parameters were observed for groups 1 and 2. Higher values of IFN-c, IL-2, IL-6 and IL-10 were observed for group 1 from the baseline to two months after treatment initiation, whereas reduced levels of TNF-a were observed for this group between 60 and 120 days of HAART. Conclusion: Independent of the immunosuppression profile at baseline, HIV-TB patients under HAART were able to recover the CD4+ T cell counts, and control viral replication and immune activation parameters over time.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPlos One
dc.rightsopen access
dc.subjectTuberculosis
dc.subjectHIV-Positive Individuals
dc.subjectAntituberculous Treatment
dc.subjectEfavirenz-Based Regimens
dc.subjectCytokine
dc.subjectT Cell Activation
dc.subjectHIV-TB patients
dc.subjectTuberculose
dc.subjectCitocinas
dc.subjectSorodiagnóstico da AIDS
dc.subjectInfecções por HIV
dc.subjectImunossupressão
dc.titleT Cell Activation and Cytokine Profile of Tuberculosis and HIV-Positive Individuals during Antituberculous Treatment and Efavirenz-Based Regimens
dc.typeArticle


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