Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion

dc.creatorRabelo, Kíssila
dc.creatorSouza, Luiz J.
dc.creatorSalomão, Natália G.
dc.creatorOliveira, Edson R. A.
dc.creatorSentinelli, Lynna de Paula
dc.creatorLacerda, Marcelle S.
dc.creatorSaraquino, Pedro B.
dc.creatorRosman, Fernando C.
dc.creatorOliveira, Rodrigo Basílio de
dc.creatorCarvalho, Jorge J.
dc.creatorPaes, Marciano V.
dc.date2018-10-01T14:53:40Z
dc.date2018-10-01T14:53:40Z
dc.date2018
dc.date.accessioned2023-09-26T20:57:33Z
dc.date.available2023-09-26T20:57:33Z
dc.identifierRABELO, Kissila; et al. Placental inflammation and fetal injury in a rare Zila case associated with Guillain-Barré Syndrome and abortion. Front. Microbiol., v.9, Article 1018, 10p, May 2018.
dc.identifier1664-302X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29198
dc.identifier10.3389/fmicb.2018.01018
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8866833
dc.descriptionZika virus (ZIKV) is an emerging virus involved in recent outbreaks in Brazil. The association between the virus and Guillain-Barré syndrome (GBS) or congenital disorders has raised a worldwide concern. In this work, we investigated a rare Zika case, which was associated with GBS and spontaneous retained abortion. Using specific anti-ZIKV staining, the virus was identified in placenta (mainly in Hofbauer cells) and in several fetal tissues, such as brain, lungs, kidneys, skin and liver. Histological analyses of the placenta and fetal organs revealed different types of tissue abnormalities, which included inflammation, hemorrhage, edema and necrosis in placenta, as well as tissue disorganization in the fetus. Increased cellularity (Hofbauer cells and TCD8+ lymphocytes), expression of local pro-inflammatory cytokines such as IFN-γ and TNF-α, and other markers, such as RANTES/CCL5 and VEGFR2, supported placental inflammation and dysfunction. The commitment of the maternal-fetal link in association with fetal damage gave rise to a discussion regarding the influence of the maternal immunity toward the fetal development. Findings presented in this work may help understanding the ZIKV immunopathogenesis under the rare contexts of spontaneous abortions in association with GBS.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectZika virus
dc.subjectResposta imune
dc.subjectSyndrome de Guillain-Barré
dc.subjectinfecção fetal
dc.subjecthistopatologia
dc.subjectZika virus
dc.subjectimmune response
dc.subjectGuillain-Barré syndrome
dc.subjectfetal infection
dc.subjecthistopathology
dc.titlePlacental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion
dc.typeArticle


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