Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies

dc.creatorSoeiro, Maria Nazaré C.
dc.creatorDantas, Andréia P.
dc.creatorDaliry, Anissa
dc.creatorSilva, Cristiane F. da
dc.creatorBatista, Denise G. J.
dc.creatorSouza, Elen M. de
dc.creatorOliveira, Gabriel M.
dc.creatorSalomão, Kelly
dc.creatorBatista, Marcos Meuser
dc.creatorPacheco, Michelle G. O.
dc.creatorSilva, Patrícia Bernardino da
dc.creatorSanta Rita, Ricardo M.
dc.creatorMenna Barreto, Rubem F. S.
dc.creatorBoykin, David W.
dc.creatorCastro, Solange Lisboa de
dc.date2019-01-08T14:21:23Z
dc.date2019-01-08T14:21:23Z
dc.date2009
dc.date.accessioned2023-09-26T20:57:31Z
dc.date.available2023-09-26T20:57:31Z
dc.identifierSOEIRO, Maria Nazaré C. et al. Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies. Mem Inst Oswaldo Cruz, v.104, Suppl. I, p.301-310, 2009.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/30920
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8866827
dc.descriptionChagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectTrypanosoma cruzi
dc.subjectDoença de Chagas
dc.subjectquimioterapia experimental
dc.subjectdiamidinas aromáticas
dc.subjectprópolis
dc.subjectnaftoquinonas
dc.subjectTrypanosoma cruzi
dc.subjectChagas Disease
dc.subjectexperimental chemotherapy
dc.subjectaromatic diamidines
dc.subjectpropolis
dc.subjectN,N-dimethyl-propenamines
dc.subjectnaphthoquinones
dc.titleExperimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
dc.typeArticle


Este ítem pertenece a la siguiente institución